Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-<i>co</i>-Glycolic Acid) Microspheres for Sustained Protein Release
In this study, poly(lactic-<i>co</i>-glycolic acid) microspheres (PLGA MS)for controlled protein release by double emulsion-solvent evaporation were produced and characterized for their morphological and technological features. MS autocatalytic degradation was described by a mathematical...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/9/2042 |
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| author | Paolo Antonio Netti Marco Biondi Mariaenrica Frigione |
| author_facet | Paolo Antonio Netti Marco Biondi Mariaenrica Frigione |
| author_sort | Paolo Antonio Netti |
| collection | DOAJ |
| description | In this study, poly(lactic-<i>co</i>-glycolic acid) microspheres (PLGA MS)for controlled protein release by double emulsion-solvent evaporation were produced and characterized for their morphological and technological features. MS autocatalytic degradation was described by a mathematical model based on a Michaelis and Menten-like chemical balance. Here, for the first time MS degradation was correlated to the advancement of MS degradation front with respect to the degraded radius, derived from mass loss experiments. The model can satisfactorily describe the kinetics of advancement of the degradation front experimentally derived for all MS formulations, especially when produced at higher PLGA concentrations. |
| first_indexed | 2024-03-10T16:29:43Z |
| format | Article |
| id | doaj.art-79e2ecf583054fd9b4a3dc65929ed072 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T16:29:43Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-79e2ecf583054fd9b4a3dc65929ed0722023-11-20T12:56:33ZengMDPI AGPolymers2073-43602020-09-01129204210.3390/polym12092042Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-<i>co</i>-Glycolic Acid) Microspheres for Sustained Protein ReleasePaolo Antonio Netti0Marco Biondi1Mariaenrica Frigione2Interdisciplinary Research Centre on Biomaterials, CRIB, Università di Napoli Federico II, P.leTecchio, 80, 80125 Napoli, ItalyInterdisciplinary Research Centre on Biomaterials, CRIB, Università di Napoli Federico II, P.leTecchio, 80, 80125 Napoli, ItalyDepartment of Innovation Engineering, University of Salento, Via Arnesano, 73100 Lecce, ItalyIn this study, poly(lactic-<i>co</i>-glycolic acid) microspheres (PLGA MS)for controlled protein release by double emulsion-solvent evaporation were produced and characterized for their morphological and technological features. MS autocatalytic degradation was described by a mathematical model based on a Michaelis and Menten-like chemical balance. Here, for the first time MS degradation was correlated to the advancement of MS degradation front with respect to the degraded radius, derived from mass loss experiments. The model can satisfactorily describe the kinetics of advancement of the degradation front experimentally derived for all MS formulations, especially when produced at higher PLGA concentrations.https://www.mdpi.com/2073-4360/12/9/2042degradation of PLGAkinetics of degradationPLGA microspheresdrug deliverymathematical modeling |
| spellingShingle | Paolo Antonio Netti Marco Biondi Mariaenrica Frigione Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-<i>co</i>-Glycolic Acid) Microspheres for Sustained Protein Release Polymers degradation of PLGA kinetics of degradation PLGA microspheres drug delivery mathematical modeling |
| title | Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-<i>co</i>-Glycolic Acid) Microspheres for Sustained Protein Release |
| title_full | Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-<i>co</i>-Glycolic Acid) Microspheres for Sustained Protein Release |
| title_fullStr | Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-<i>co</i>-Glycolic Acid) Microspheres for Sustained Protein Release |
| title_full_unstemmed | Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-<i>co</i>-Glycolic Acid) Microspheres for Sustained Protein Release |
| title_short | Experimental Studies and Modeling of the Degradation Process of Poly(Lactic-<i>co</i>-Glycolic Acid) Microspheres for Sustained Protein Release |
| title_sort | experimental studies and modeling of the degradation process of poly lactic i co i glycolic acid microspheres for sustained protein release |
| topic | degradation of PLGA kinetics of degradation PLGA microspheres drug delivery mathematical modeling |
| url | https://www.mdpi.com/2073-4360/12/9/2042 |
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