Urinary tract infections in children with cancer and febrile neutropenia - single center experience
Background/Aim. Urinary tract infection (UTI) in children with febrile neutropenia (FN) after receiving chemotherapy could be followed by atypical symptoms and signs. The absence of routine urine culture (UC) sampling for analysis could lead to undiagnosed disease and inadequate treatment of these p...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2024-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502300057K.pdf |
| _version_ | 1797215429416976384 |
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| author | Kovač Nataša Samardžić-Lukić Maja Kaćanski Nataša Kovač Aleksandra Latinović Tijana Kolarović Jovanka |
| author_facet | Kovač Nataša Samardžić-Lukić Maja Kaćanski Nataša Kovač Aleksandra Latinović Tijana Kolarović Jovanka |
| author_sort | Kovač Nataša |
| collection | DOAJ |
| description | Background/Aim. Urinary tract infection (UTI) in children with febrile neutropenia (FN) after receiving chemotherapy could be followed by atypical symptoms and signs. The absence of routine urine culture (UC) sampling for analysis could lead to undiagnosed disease and inadequate treatment of these patients. The aim of the study was to indicate the importance of sampling UC in children who have developed FN and to point out the most probable causative agents of UTI in children with FN and antibiotic sensitivity/resistance of the isolated strains. Methods. During a five-year observation period, 40 UTIs were registered in 30 patients with FN. In the study group of patients with FN, the number of UTIs, the number of recurrent UTIs, isolated pathogens, their sensitivity to antibiotics, characteristics of urine sediment, the presence of localized symptoms of UTI, and the presence of urosepsis were analyzed. The obtained results were compared with the control group which consisted of children who were healthy prior to hospitalization due to febrile urinary infection. Results. When compared to the control group, significant differences in the presence of symptoms of UTI and urine sediment findings in patients with FN were observed. A higher percentage of resistant strains of Escherichia coli isolated from UC of cancer patients with FN was noted when compared to the control group. Three UTI cases were followed by urosepsis. Conclusion. UC findings are important not only in establishing the diagnosis of UTI and detecting multi-resistant bacterial strains but also in choosing appropriate antibiotics and selecting a subgroup of patients with recurrent UTI who require further monitoring and detecting potential complications in a timely manner. |
| first_indexed | 2024-04-24T11:29:56Z |
| format | Article |
| id | doaj.art-79e35283b0814c39bc46dbaaa7a2ad09 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-04-24T11:29:56Z |
| publishDate | 2024-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-79e35283b0814c39bc46dbaaa7a2ad092024-04-10T10:28:43ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202024-01-01811343810.2298/VSP230620057K0042-84502300057KUrinary tract infections in children with cancer and febrile neutropenia - single center experienceKovač Nataša0https://orcid.org/0000-0002-8269-6675Samardžić-Lukić Maja1Kaćanski Nataša2https://orcid.org/0000-0001-9902-8676Kovač Aleksandra3https://orcid.org/0000-0001-6059-083XLatinović Tijana4Kolarović Jovanka5https://orcid.org/0000-0001-7240-0773Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaInstitute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaInstitute for Child and Youth Health Care of Vojvodina, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Oncology Institute of Vojvodina, Sremska Kamenica, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, SerbiaInstitute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaBackground/Aim. Urinary tract infection (UTI) in children with febrile neutropenia (FN) after receiving chemotherapy could be followed by atypical symptoms and signs. The absence of routine urine culture (UC) sampling for analysis could lead to undiagnosed disease and inadequate treatment of these patients. The aim of the study was to indicate the importance of sampling UC in children who have developed FN and to point out the most probable causative agents of UTI in children with FN and antibiotic sensitivity/resistance of the isolated strains. Methods. During a five-year observation period, 40 UTIs were registered in 30 patients with FN. In the study group of patients with FN, the number of UTIs, the number of recurrent UTIs, isolated pathogens, their sensitivity to antibiotics, characteristics of urine sediment, the presence of localized symptoms of UTI, and the presence of urosepsis were analyzed. The obtained results were compared with the control group which consisted of children who were healthy prior to hospitalization due to febrile urinary infection. Results. When compared to the control group, significant differences in the presence of symptoms of UTI and urine sediment findings in patients with FN were observed. A higher percentage of resistant strains of Escherichia coli isolated from UC of cancer patients with FN was noted when compared to the control group. Three UTI cases were followed by urosepsis. Conclusion. UC findings are important not only in establishing the diagnosis of UTI and detecting multi-resistant bacterial strains but also in choosing appropriate antibiotics and selecting a subgroup of patients with recurrent UTI who require further monitoring and detecting potential complications in a timely manner.https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502300057K.pdfbacteriological techniqueschildfebrile neutropeniamedical oncologyurinary tract infectionurinalysis |
| spellingShingle | Kovač Nataša Samardžić-Lukić Maja Kaćanski Nataša Kovač Aleksandra Latinović Tijana Kolarović Jovanka Urinary tract infections in children with cancer and febrile neutropenia - single center experience Vojnosanitetski Pregled bacteriological techniques child febrile neutropenia medical oncology urinary tract infection urinalysis |
| title | Urinary tract infections in children with cancer and febrile neutropenia - single center experience |
| title_full | Urinary tract infections in children with cancer and febrile neutropenia - single center experience |
| title_fullStr | Urinary tract infections in children with cancer and febrile neutropenia - single center experience |
| title_full_unstemmed | Urinary tract infections in children with cancer and febrile neutropenia - single center experience |
| title_short | Urinary tract infections in children with cancer and febrile neutropenia - single center experience |
| title_sort | urinary tract infections in children with cancer and febrile neutropenia single center experience |
| topic | bacteriological techniques child febrile neutropenia medical oncology urinary tract infection urinalysis |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502300057K.pdf |
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