High-throughput analysis of the Trypanosoma cruzi minicirculome (mcDNA) unveils structural variation and functional diversity

High-throughput analysis of the Trypanosoma cruzi minicirculome (mcDNA) unveils structural variation and functional diversity

Abstract Trypanosoma cruzi causes Chagas disease and has a unique extranuclear genome enclosed in a structure called the kinetoplast, which contains circular genomes known as maxi- and minicircles. While the structure and function of maxicircles are well-understood, many aspects of minicircles remai...

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Bibliographic Details
Main Authors: Andrés Gómez-Palacio, Lissa Cruz-Saavedra, Frederik Van den Broeck, Manon Geerts, Sebastián Pita, Gustavo A. Vallejo, Julio C. Carranza, Juan David Ramírez
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Trypanosoma cruzi
Maxicircles
Minicircles
kDNA
Guide RNA
Colombia
Online Access:https://doi.org/10.1038/s41598-024-56076-4

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