Association of Plasma and Aqueous Humor Ascorbic Acid Level with Morphology Pattern of Age-Related Cataract
Background: Age-related cataract is one of the most important causes of preventable blindness among elderly population in the world. Among various causes of cataract, the level of ascorbic acid in the plasma and aqueous humor is an important parameter that can prevent cataract formation. The level o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nobel Medical College Teaching Hospital
2020-06-01
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| Series: | Journal of Nobel Medical College |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/JoNMC/article/view/29491 |
| _version_ | 1818826249824370688 |
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| author | Shailesh Mani Pokharel Poonam Lavaju Bhuwan Govinda Shrestha Seraj Ahmed Khan Sangeeta Shah |
| author_facet | Shailesh Mani Pokharel Poonam Lavaju Bhuwan Govinda Shrestha Seraj Ahmed Khan Sangeeta Shah |
| author_sort | Shailesh Mani Pokharel |
| collection | DOAJ |
| description | Background: Age-related cataract is one of the most important causes of preventable blindness among elderly population in the world. Among various causes of cataract, the level of ascorbic acid in the plasma and aqueous humor is an important parameter that can prevent cataract formation. The level of ascorbic acid in the plasma and aqueous humor is also an indicator of various morphological pattern of cataract.
Materials and Methods: A hospital-based cross-sectional study was conducted among 136 patients with immature age-related cataract (≥50 years) who underwent Manual Small Incision Cataract Surgery in the Ophthalmology Department of BPKIHS for the duration of 1 year. Plasma and aqueous humor ascorbic acid levels were determined by standard competitive ELISA test.
Results: Ascorbic acid concentrations in aqueous humor as well as plasma were statistically significant with the nuclear type of cataract (p<0.001). There was a positive correlation between plasma and aqueous ascorbic acid level with r = 0.532 and p<0.001.
Conclusion: The finding of the study concludes that nuclear type of cataract has a strong association with both aqueous humor and plasma ascorbic acid level. |
| first_indexed | 2024-12-19T00:24:40Z |
| format | Article |
| id | doaj.art-79e5eab9f0b04e209a30c9c9a70a8d2a |
| institution | Directory Open Access Journal |
| issn | 2091-2331 2091-234X |
| language | English |
| last_indexed | 2024-12-19T00:24:40Z |
| publishDate | 2020-06-01 |
| publisher | Nobel Medical College Teaching Hospital |
| record_format | Article |
| series | Journal of Nobel Medical College |
| spelling | doaj.art-79e5eab9f0b04e209a30c9c9a70a8d2a2022-12-21T20:45:20ZengNobel Medical College Teaching HospitalJournal of Nobel Medical College2091-23312091-234X2020-06-0191364010.3126/jonmc.v9i1.2949129491Association of Plasma and Aqueous Humor Ascorbic Acid Level with Morphology Pattern of Age-Related CataractShailesh Mani Pokharel0Poonam Lavaju1Bhuwan Govinda Shrestha2Seraj Ahmed Khan3Sangeeta Shah4Department of Ophthalmology, B.P. Koirala Institute of Health Sciences, Dharan, NepalDepartment of Ophthalmology, B.P. Koirala Institute of Health Sciences, Dharan, NepalDepartment of Ophthalmology, B.P. Koirala Institute of Health Sciences, Dharan, NepalDepartment of Biochemistry, B.P. Koirala Institute of Health Sciences, Dharan, NepalDepartment of Ophthalmology, B.P. Koirala Institute of Health Sciences, Dharan, NepalBackground: Age-related cataract is one of the most important causes of preventable blindness among elderly population in the world. Among various causes of cataract, the level of ascorbic acid in the plasma and aqueous humor is an important parameter that can prevent cataract formation. The level of ascorbic acid in the plasma and aqueous humor is also an indicator of various morphological pattern of cataract. Materials and Methods: A hospital-based cross-sectional study was conducted among 136 patients with immature age-related cataract (≥50 years) who underwent Manual Small Incision Cataract Surgery in the Ophthalmology Department of BPKIHS for the duration of 1 year. Plasma and aqueous humor ascorbic acid levels were determined by standard competitive ELISA test. Results: Ascorbic acid concentrations in aqueous humor as well as plasma were statistically significant with the nuclear type of cataract (p<0.001). There was a positive correlation between plasma and aqueous ascorbic acid level with r = 0.532 and p<0.001. Conclusion: The finding of the study concludes that nuclear type of cataract has a strong association with both aqueous humor and plasma ascorbic acid level.https://www.nepjol.info/index.php/JoNMC/article/view/29491aqueous humorascorbic acidcataractplasma |
| spellingShingle | Shailesh Mani Pokharel Poonam Lavaju Bhuwan Govinda Shrestha Seraj Ahmed Khan Sangeeta Shah Association of Plasma and Aqueous Humor Ascorbic Acid Level with Morphology Pattern of Age-Related Cataract Journal of Nobel Medical College aqueous humor ascorbic acid cataract plasma |
| title | Association of Plasma and Aqueous Humor Ascorbic Acid Level with Morphology Pattern of Age-Related Cataract |
| title_full | Association of Plasma and Aqueous Humor Ascorbic Acid Level with Morphology Pattern of Age-Related Cataract |
| title_fullStr | Association of Plasma and Aqueous Humor Ascorbic Acid Level with Morphology Pattern of Age-Related Cataract |
| title_full_unstemmed | Association of Plasma and Aqueous Humor Ascorbic Acid Level with Morphology Pattern of Age-Related Cataract |
| title_short | Association of Plasma and Aqueous Humor Ascorbic Acid Level with Morphology Pattern of Age-Related Cataract |
| title_sort | association of plasma and aqueous humor ascorbic acid level with morphology pattern of age related cataract |
| topic | aqueous humor ascorbic acid cataract plasma |
| url | https://www.nepjol.info/index.php/JoNMC/article/view/29491 |
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