HDX-MS for Epitope Characterization of a Therapeutic ANTIBODY Candidate on the Calcium-Binding Protein Annexin-A1

HDX-MS for Epitope Characterization of a Therapeutic ANTIBODY Candidate on the Calcium-Binding Protein Annexin-A1

Annexin-A1 (ANXA1) belongs to a class of highly homologous Ca<sup>2+</sup>-dependent phospholipid-binding proteins. Its structure consists of a core region composed of four homologous repeats arranged in a compact, hydrolysis-resistant structure and an N-terminal region with a Ca<sup&...

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Bibliographic Details
Main Authors: Marius Gramlich, Henry C. W. Hays, Scott Crichton, Philipp D. Kaiser, Anne Heine, Nicole Schneiderhan-Marra, Ulrich Rothbauer, Dieter Stoll, Sandra Maier, Anne Zeck
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antibodies
Subjects:
HDX-MS
hydrogen–deuterium exchange
mass spectrometry
proteolysis-resistant protein
ANXA1
annexin-A1
Online Access:https://www.mdpi.com/2073-4468/10/1/11

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