Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression

Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression

Aggregation of alpha-synuclein (aSyn) is closely linked to Parkinson's disease, probably due to the loss of physiological functions and/or gain of toxic functions of aggregated aSyn. Significant efforts have been made elucidating the physiological structure and function of aSyn, however, with l...

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Bibliographic Details
Main Authors: Yanni Schneider, Soeren Turan, Aron Koller, Mandy Krumbiegel, Michaela Farrell, Sonja Plötz, Jürgen Winkler, Wei Xiang
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506122003014

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http://www.sciencedirect.com/science/article/pii/S1873506122003014

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