MOLECULAR-GENETIC FACTORS, ASSOCIATED WITH AORTIC STENOSIS DEVELOPMENT
Aortic stenosis (AS) is one of the most prevalent valvular heart disorders in patients older than 65 years. Regardless the studied molecular mechanisms of development and progression of the disease, surgical treatment is recently the only successful method of help. Due to lots of comorbidities of ol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2015-10-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/325 |
| _version_ | 1797856954318585856 |
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| author | T. A. Tipteva O. S. Chumakova D. A. Zateyshchikov |
| author_facet | T. A. Tipteva O. S. Chumakova D. A. Zateyshchikov |
| author_sort | T. A. Tipteva |
| collection | DOAJ |
| description | Aortic stenosis (AS) is one of the most prevalent valvular heart disorders in patients older than 65 years. Regardless the studied molecular mechanisms of development and progression of the disease, surgical treatment is recently the only successful method of help. Due to lots of comorbidities of older patients, there are obstacles to recommend surgical valve replacement, even knowing an adverse prognosis of conservative treatment. Search for new approaches to earlier assessment of adverse risk factors, speed of progression of this disease, would help to evaluate the necessity of earlier treatment and could make to slow down the progression of the disease. One of directions for this — is a search for genetic markers. This review focuses on the main known molecular mechanisms and genetic markers related to them, that are associated with AS. |
| first_indexed | 2024-04-09T20:49:58Z |
| format | Article |
| id | doaj.art-79e840f084f3438d9589e917a8afc8d3 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:49:58Z |
| publishDate | 2015-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-79e840f084f3438d9589e917a8afc8d32023-03-29T21:23:24Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202015-10-010109910610.15829/1560-4071-2015-10-99-106325MOLECULAR-GENETIC FACTORS, ASSOCIATED WITH AORTIC STENOSIS DEVELOPMENTT. A. Tipteva0O. S. Chumakova1D. A. Zateyshchikov2Central state medical Academy of the administrative Department of the President of the Russian Federation, MoscowCentral state medical Academy of the administrative Department of the President of the Russian Federation, MoscowCity Clinical Hospital №51, Moscow; Central state medical Academy of the administrative Department of the President of the Russian Federation, Moscow; Federal scientific-clinical center of specialized types of clinical care and medical technologies of FMBA of Russia, MoscowAortic stenosis (AS) is one of the most prevalent valvular heart disorders in patients older than 65 years. Regardless the studied molecular mechanisms of development and progression of the disease, surgical treatment is recently the only successful method of help. Due to lots of comorbidities of older patients, there are obstacles to recommend surgical valve replacement, even knowing an adverse prognosis of conservative treatment. Search for new approaches to earlier assessment of adverse risk factors, speed of progression of this disease, would help to evaluate the necessity of earlier treatment and could make to slow down the progression of the disease. One of directions for this — is a search for genetic markers. This review focuses on the main known molecular mechanisms and genetic markers related to them, that are associated with AS.https://russjcardiol.elpub.ru/jour/article/view/325aortic stenosishereditary predisposition |
| spellingShingle | T. A. Tipteva O. S. Chumakova D. A. Zateyshchikov MOLECULAR-GENETIC FACTORS, ASSOCIATED WITH AORTIC STENOSIS DEVELOPMENT Российский кардиологический журнал aortic stenosis hereditary predisposition |
| title | MOLECULAR-GENETIC FACTORS, ASSOCIATED WITH AORTIC STENOSIS DEVELOPMENT |
| title_full | MOLECULAR-GENETIC FACTORS, ASSOCIATED WITH AORTIC STENOSIS DEVELOPMENT |
| title_fullStr | MOLECULAR-GENETIC FACTORS, ASSOCIATED WITH AORTIC STENOSIS DEVELOPMENT |
| title_full_unstemmed | MOLECULAR-GENETIC FACTORS, ASSOCIATED WITH AORTIC STENOSIS DEVELOPMENT |
| title_short | MOLECULAR-GENETIC FACTORS, ASSOCIATED WITH AORTIC STENOSIS DEVELOPMENT |
| title_sort | molecular genetic factors associated with aortic stenosis development |
| topic | aortic stenosis hereditary predisposition |
| url | https://russjcardiol.elpub.ru/jour/article/view/325 |
| work_keys_str_mv | AT tatipteva moleculargeneticfactorsassociatedwithaorticstenosisdevelopment AT oschumakova moleculargeneticfactorsassociatedwithaorticstenosisdevelopment AT dazateyshchikov moleculargeneticfactorsassociatedwithaorticstenosisdevelopment |