Selective Nerve Fibre Activation in Patients with Generalized Chronic Pruritus: Hint for Central Sensitization?
Central sensitization induces pain augmentation in chronic pain states. An analogous mechanism is speculated for chronic pruritus. This study compared patients with chronic pruritus (n = 79) of different origins (atopic dermatitis, chronic pruritus on non-lesional skin, chronic prurigo) and healthy...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2019-08-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3261
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| _version_ | 1819294382957789184 |
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| author | Manuel P. Pereira Konstantin Agelopoulos Johannes Köllner Gitta Neufang Martin Schmelz Sonja Ständer |
| author_facet | Manuel P. Pereira Konstantin Agelopoulos Johannes Köllner Gitta Neufang Martin Schmelz Sonja Ständer |
| author_sort | Manuel P. Pereira |
| collection | DOAJ |
| description | Central sensitization induces pain augmentation in chronic pain states. An analogous mechanism is speculated for chronic pruritus. This study compared patients with chronic pruritus (n = 79) of different origins (atopic dermatitis, chronic pruritus on non-lesional skin, chronic prurigo) and healthy controls (HC, n = 54) with regard to itch intensity and qualities of sensory symptoms after selective peripheral nerve fibre activation by electrical stimulation at 5 Hz (surrogate for C-fibre function) and 2,000 Hz (surrogate for Aβ-fibre function) using a Neurometer®. Electrically-induced itch was more intense in patients with chronic pruritus than in HC, but patients with chronic pruritus did not report “itch” more often than HC at 5 Hz. Stimulation at 2,000 Hz induced more pricking and tingling, but less throbbing in patients with chronic pruritus compared with HC. Treatment with cooling compound reduced clinical and experimental itch, but did not alter the distribution of sensory symptoms. These data show hyperknesis in chronic pruritus of various origins, arguing for common central sensitization mechanisms. |
| first_indexed | 2024-12-24T04:25:26Z |
| format | Article |
| id | doaj.art-79e8985858104db29738c711c3c9099a |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-12-24T04:25:26Z |
| publishDate | 2019-08-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-79e8985858104db29738c711c3c9099a2022-12-21T17:15:39ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572019-08-0199111009101510.2340/00015555-32615527Selective Nerve Fibre Activation in Patients with Generalized Chronic Pruritus: Hint for Central Sensitization?Manuel P. Pereira0Konstantin AgelopoulosJohannes KöllnerGitta NeufangMartin SchmelzSonja Ständer Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Von- Esmarch-Str. 58, DE-48149 Münster, Germany. manuelpedro.pereira@ukmuenster.de. Central sensitization induces pain augmentation in chronic pain states. An analogous mechanism is speculated for chronic pruritus. This study compared patients with chronic pruritus (n = 79) of different origins (atopic dermatitis, chronic pruritus on non-lesional skin, chronic prurigo) and healthy controls (HC, n = 54) with regard to itch intensity and qualities of sensory symptoms after selective peripheral nerve fibre activation by electrical stimulation at 5 Hz (surrogate for C-fibre function) and 2,000 Hz (surrogate for Aβ-fibre function) using a Neurometer®. Electrically-induced itch was more intense in patients with chronic pruritus than in HC, but patients with chronic pruritus did not report “itch” more often than HC at 5 Hz. Stimulation at 2,000 Hz induced more pricking and tingling, but less throbbing in patients with chronic pruritus compared with HC. Treatment with cooling compound reduced clinical and experimental itch, but did not alter the distribution of sensory symptoms. These data show hyperknesis in chronic pruritus of various origins, arguing for common central sensitization mechanisms. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3261 neurometer electrical stimulation C-fibre Aβ-fibre chronic pruritus |
| spellingShingle | Manuel P. Pereira Konstantin Agelopoulos Johannes Köllner Gitta Neufang Martin Schmelz Sonja Ständer Selective Nerve Fibre Activation in Patients with Generalized Chronic Pruritus: Hint for Central Sensitization? Acta Dermato-Venereologica neurometer electrical stimulation C-fibre Aβ-fibre chronic pruritus |
| title | Selective Nerve Fibre Activation in Patients with Generalized Chronic Pruritus: Hint for Central Sensitization? |
| title_full | Selective Nerve Fibre Activation in Patients with Generalized Chronic Pruritus: Hint for Central Sensitization? |
| title_fullStr | Selective Nerve Fibre Activation in Patients with Generalized Chronic Pruritus: Hint for Central Sensitization? |
| title_full_unstemmed | Selective Nerve Fibre Activation in Patients with Generalized Chronic Pruritus: Hint for Central Sensitization? |
| title_short | Selective Nerve Fibre Activation in Patients with Generalized Chronic Pruritus: Hint for Central Sensitization? |
| title_sort | selective nerve fibre activation in patients with generalized chronic pruritus hint for central sensitization |
| topic | neurometer electrical stimulation C-fibre Aβ-fibre chronic pruritus |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3261
|
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