Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau

Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau

Age is the largest risk factor for Alzheimer’s disease (AD) and contributes to cognitive impairment in otherwise healthy individuals. Thus, it is critical that we better understand the risk aging presents to vulnerable regions of the brain and carefully design therapeutics to address those effects....

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Bibliographic Details
Main Authors: Shannon N. Leslie, Dibyadeep Datta, Kyle R. Christensen, Christopher H. van Dyck, Amy F. T. Arnsten, Angus C. Nairn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
tau
working memory
PDE4D
aging
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.576723/full

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