Targeting the gut microbial metabolic pathway with small molecules decreases uremic toxin production

Targeting the gut microbial metabolic pathway with small molecules decreases uremic toxin production

Uremic toxins are a class of toxins that accumulate in patients with chronic kidney disease (CKD). Indoxyl sulfate (IS), a typical uremic toxin, is not efficiently removed by hemodialysis. Modulation of IS production in the gut microbiota may be a promising strategy for decreasing IS concentration,...

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Bibliographic Details
Main Authors: Yingyi Wang, Jianping Li, Chenkai Chen, Jingbo Lu, Jingao Yu, Xuejun Xu, Yin Peng, Sen Zhang, Shu Jiang, Jianming Guo, Jinao Duan
Format: Article
Language:English
Published: Taylor & Francis Group 2020-11-01
Series:Gut Microbes
Subjects:
gut microbiota
chronic kidney disease
uremic toxin
indoxyl sulfate
indole
isoquercitrin
Online Access:http://dx.doi.org/10.1080/19490976.2020.1823800

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