Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension
Background: Balloon pulmonary angioplasty (BPA) is a treatment option for patients with chronic thromboembolic pulmonary hypertension (CTEPH). Methods and results: In 60 patients with CTEPH, we examined the hemodynamic data before and after BPA. In addition, the sequential ECG findings for right ven...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906718300186 |
| _version_ | 1819041535593807872 |
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| author | Takahiko Nishiyama Seiji Takatsuki Takashi Kawakami Yoshinori Katsumata Takehiro Kimura Masaharu Kataoka Hikaru Tsuruta Yuji Itabashi Mitsushige Murata Shinsuke Yuasa Yoshiyasu Aizawa Keiichi Fukuda |
| author_facet | Takahiko Nishiyama Seiji Takatsuki Takashi Kawakami Yoshinori Katsumata Takehiro Kimura Masaharu Kataoka Hikaru Tsuruta Yuji Itabashi Mitsushige Murata Shinsuke Yuasa Yoshiyasu Aizawa Keiichi Fukuda |
| author_sort | Takahiko Nishiyama |
| collection | DOAJ |
| description | Background: Balloon pulmonary angioplasty (BPA) is a treatment option for patients with chronic thromboembolic pulmonary hypertension (CTEPH). Methods and results: In 60 patients with CTEPH, we examined the hemodynamic data before and after BPA. In addition, the sequential ECG findings for right ventricular hypertrophy (RVH) were assessed. The mean pulmonary arterial pressure (mPAP) decreased from 38 ± 11 to 20 ± 4 mm Hg (p < 0.05). The ROC analysis showed that the S waves in V5, R waves in V1 + S waves in V5, S waves in I, and QRS axis were significant predictors of an mPAP ≧ 30 mm Hg (AUC > 0.75, p < 0.01). The predictive values for the mPAP before the BPA were the S and R waves in lead V6, and P waves in lead II (33.417 + 0.078 × P in II − 0.10 × R in V6 + 0.012 × S in V6). The change in the mPAP (ΔmPAP) correlated with the change in the amplitudes of the ECGs: ΔS wave in lead I (R = 0.544, p < 0.001), ΔR in V1 + S in V5 (R = 0.476, p < 0.001), and ΔP wave in II (R = 0.511, p < 0.001). At 6 months of follow-up, the improvement in an R in V1 + S in V5 of ≧10 mm implied a better functional status. Conclusion: BPA therapy reduced the pulmonary arterial pressure in patients with CTEPH and was associated with an improvement in the ECG findings related to RVH. Keywords: Chronic thromboembolic pulmonary hypertension, Balloon pulmonary angioplasty, Electrocardiogram, Right ventricular hypertrophy |
| first_indexed | 2024-12-21T09:26:32Z |
| format | Article |
| id | doaj.art-79ec53db499d4cb084996e31b1737af8 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-21T09:26:32Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
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| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-79ec53db499d4cb084996e31b1737af82022-12-21T19:08:53ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672018-06-01197582Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertensionTakahiko Nishiyama0Seiji Takatsuki1Takashi Kawakami2Yoshinori Katsumata3Takehiro Kimura4Masaharu Kataoka5Hikaru Tsuruta6Yuji Itabashi7Mitsushige Murata8Shinsuke Yuasa9Yoshiyasu Aizawa10Keiichi Fukuda11Corresponding author at: Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.; Department of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanDepartment of Cardiology, Keio University School of Medicine, JapanBackground: Balloon pulmonary angioplasty (BPA) is a treatment option for patients with chronic thromboembolic pulmonary hypertension (CTEPH). Methods and results: In 60 patients with CTEPH, we examined the hemodynamic data before and after BPA. In addition, the sequential ECG findings for right ventricular hypertrophy (RVH) were assessed. The mean pulmonary arterial pressure (mPAP) decreased from 38 ± 11 to 20 ± 4 mm Hg (p < 0.05). The ROC analysis showed that the S waves in V5, R waves in V1 + S waves in V5, S waves in I, and QRS axis were significant predictors of an mPAP ≧ 30 mm Hg (AUC > 0.75, p < 0.01). The predictive values for the mPAP before the BPA were the S and R waves in lead V6, and P waves in lead II (33.417 + 0.078 × P in II − 0.10 × R in V6 + 0.012 × S in V6). The change in the mPAP (ΔmPAP) correlated with the change in the amplitudes of the ECGs: ΔS wave in lead I (R = 0.544, p < 0.001), ΔR in V1 + S in V5 (R = 0.476, p < 0.001), and ΔP wave in II (R = 0.511, p < 0.001). At 6 months of follow-up, the improvement in an R in V1 + S in V5 of ≧10 mm implied a better functional status. Conclusion: BPA therapy reduced the pulmonary arterial pressure in patients with CTEPH and was associated with an improvement in the ECG findings related to RVH. Keywords: Chronic thromboembolic pulmonary hypertension, Balloon pulmonary angioplasty, Electrocardiogram, Right ventricular hypertrophyhttp://www.sciencedirect.com/science/article/pii/S2352906718300186 |
| spellingShingle | Takahiko Nishiyama Seiji Takatsuki Takashi Kawakami Yoshinori Katsumata Takehiro Kimura Masaharu Kataoka Hikaru Tsuruta Yuji Itabashi Mitsushige Murata Shinsuke Yuasa Yoshiyasu Aizawa Keiichi Fukuda Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension International Journal of Cardiology: Heart & Vasculature |
| title | Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension |
| title_full | Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension |
| title_fullStr | Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension |
| title_full_unstemmed | Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension |
| title_short | Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension |
| title_sort | improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension |
| url | http://www.sciencedirect.com/science/article/pii/S2352906718300186 |
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