Artemin Is Upregulated by TrkB Agonist and Protects the Immature Retina Against Hypoxic-Ischemic Injury by Suppressing Neuroinflammation and Astrogliosis

Artemin Is Upregulated by TrkB Agonist and Protects the Immature Retina Against Hypoxic-Ischemic Injury by Suppressing Neuroinflammation and Astrogliosis

Hypoxic-ischemia (HI) is a major cause of acquired visual impairment in children from developed countries. Previous studies have shown that systemic administration of 7,8-dihydroxyavone (DHF), a selective tropomyosin receptor kinase B (TrkB) agonist, provides long-term neuroprotection against HI inj...

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Bibliographic Details
Main Authors: Hsiu-Mei Huang, Chao-Ching Huang, Linda Yi-Chieh Poon, Ying-Chao Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Artemin (ARTN)
astrogliosis
c-Jun N-terminal kinase (JNK)
extracellular signal-regulated kinase (ERK)
hypoxic-ischemia injury
immature retina
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.645000/full

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