Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc
We conducted a systematic review to assess the potential pulmonary carcinogenicity of inhaled talc in humans. Our systematic review methods adhere to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and incorporated aspects from the US Institute of Medicine (IOM...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.989111/full |
| _version_ | 1811241890115223552 |
|---|---|
| author | Heather N. Lynch Daniel J. Lauer William J. Thompson Olivia Leleck Rachel D. Freid Justin Collins Kathleen Chen A. Michael Ierardi Ania M. Urban Michael A. Cappello Paolo Boffetta Paolo Boffetta Kenneth A. Mundt |
| author_facet | Heather N. Lynch Daniel J. Lauer William J. Thompson Olivia Leleck Rachel D. Freid Justin Collins Kathleen Chen A. Michael Ierardi Ania M. Urban Michael A. Cappello Paolo Boffetta Paolo Boffetta Kenneth A. Mundt |
| author_sort | Heather N. Lynch |
| collection | DOAJ |
| description | We conducted a systematic review to assess the potential pulmonary carcinogenicity of inhaled talc in humans. Our systematic review methods adhere to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and incorporated aspects from the US Institute of Medicine (IOM) and several United States (US) Environmental Protection Agency (EPA) frameworks for systematic reviews. A comprehensive literature search was conducted. Detailed data abstraction and study quality evaluation, adapting the US Toxic Substances Control Act (TSCA) framework, were central to our analysis. The literature search and selection process identified 23 primary studies that assessed exposure to talc and pulmonary cancer risks in humans (n = 19) and animals (n = 3). Integrating all streams of evidence according to the IOM framework yielded classifications of suggestive evidence of no association between inhaled talc and lung cancer and pleural mesothelioma at human-relevant exposure levels. |
| first_indexed | 2024-04-12T13:43:03Z |
| format | Article |
| id | doaj.art-79edd2b6e88649428fe2c638dcc94d25 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-12T13:43:03Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-79edd2b6e88649428fe2c638dcc94d252022-12-22T03:30:47ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.989111989111Systematic review of the scientific evidence of the pulmonary carcinogenicity of talcHeather N. Lynch0Daniel J. Lauer1William J. Thompson2Olivia Leleck3Rachel D. Freid4Justin Collins5Kathleen Chen6A. Michael Ierardi7Ania M. Urban8Michael A. Cappello9Paolo Boffetta10Paolo Boffetta11Kenneth A. Mundt12ChemRisk (Stantec), Boston, MA, United StatesChemRisk (Stantec), Boston, MA, United StatesChemRisk (Stantec), Boston, MA, United StatesChemRisk (Stantec), Boston, MA, United StatesChemRisk (Stantec), Boston, MA, United StatesChemRisk (Stantec), Boston, MA, United StatesChemRisk (Stantec), Boston, MA, United StatesChemRisk (Stantec), Boston, MA, United StatesChemRisk (Stantec), Boston, MA, United StatesChemRisk (Stantec), Boston, MA, United StatesPopulation Sciences, Stony Brook Cancer Center, Stony Brook, NY, United StatesDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, ItalyChemRisk (Stantec), Boston, MA, United StatesWe conducted a systematic review to assess the potential pulmonary carcinogenicity of inhaled talc in humans. Our systematic review methods adhere to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and incorporated aspects from the US Institute of Medicine (IOM) and several United States (US) Environmental Protection Agency (EPA) frameworks for systematic reviews. A comprehensive literature search was conducted. Detailed data abstraction and study quality evaluation, adapting the US Toxic Substances Control Act (TSCA) framework, were central to our analysis. The literature search and selection process identified 23 primary studies that assessed exposure to talc and pulmonary cancer risks in humans (n = 19) and animals (n = 3). Integrating all streams of evidence according to the IOM framework yielded classifications of suggestive evidence of no association between inhaled talc and lung cancer and pleural mesothelioma at human-relevant exposure levels.https://www.frontiersin.org/articles/10.3389/fpubh.2022.989111/fullsystematic reviewtalchazard assessmentcarcinogenicityrisk assessmentlung cancer |
| spellingShingle | Heather N. Lynch Daniel J. Lauer William J. Thompson Olivia Leleck Rachel D. Freid Justin Collins Kathleen Chen A. Michael Ierardi Ania M. Urban Michael A. Cappello Paolo Boffetta Paolo Boffetta Kenneth A. Mundt Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc Frontiers in Public Health systematic review talc hazard assessment carcinogenicity risk assessment lung cancer |
| title | Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc |
| title_full | Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc |
| title_fullStr | Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc |
| title_full_unstemmed | Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc |
| title_short | Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc |
| title_sort | systematic review of the scientific evidence of the pulmonary carcinogenicity of talc |
| topic | systematic review talc hazard assessment carcinogenicity risk assessment lung cancer |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.989111/full |
| work_keys_str_mv | AT heathernlynch systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT danieljlauer systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT williamjthompson systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT olivialeleck systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT racheldfreid systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT justincollins systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT kathleenchen systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT amichaelierardi systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT aniamurban systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT michaelacappello systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT paoloboffetta systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT paoloboffetta systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc AT kennethamundt systematicreviewofthescientificevidenceofthepulmonarycarcinogenicityoftalc |