Design of Hybrid Polymeric-Lipid Nanoparticles Using Curcumin as a Model: Preparation, Characterization, and In Vitro Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin-Loaded Nanoparticles

Design of Hybrid Polymeric-Lipid Nanoparticles Using Curcumin as a Model: Preparation, Characterization, and In Vitro Evaluation of Demethoxycurcumin and Bisdemethoxycurcumin-Loaded Nanoparticles

Polymeric lipid hybrid nanoparticles (PLHNs) are the new generation of drug delivery systems that has emerged as a combination of a polymeric core and lipid shell. We designed and optimized a simple method for the preparation of Pluronic F-127-based PLHNs able to load separately demethoxycurcumin (D...

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Bibliographic Details
Main Authors: Krissia Wilhelm Romero, María Isabel Quirós, Felipe Vargas Huertas, José Roberto Vega-Baudrit, Mirtha Navarro-Hoyos, Andrea Mariela Araya-Sibaja
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Polymers
Subjects:
drug delivery
polymer-lipid hybrid nanoparticles
curcumin
demethoxycurcumin
bisdemethoxycurcumin
Pluronic F-127
Online Access:https://www.mdpi.com/2073-4360/13/23/4207

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