Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration
Abstract Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical manifestation that has the potential to cause severe oral and/or systemic diseases and compromise quality of life. Currently, the standard-of-care for this condition remains palliative. A variety of appro...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-05-01
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| Series: | International Journal of Oral Science |
| Online Access: | https://doi.org/10.1038/s41368-023-00224-5 |
| _version_ | 1797827647651184640 |
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| author | Milos Marinkovic Olivia N. Tran Hanzhou Wang Parveez Abdul-Azees David D. Dean Xiao-Dong Chen Chih-Ko Yeh |
| author_facet | Milos Marinkovic Olivia N. Tran Hanzhou Wang Parveez Abdul-Azees David D. Dean Xiao-Dong Chen Chih-Ko Yeh |
| author_sort | Milos Marinkovic |
| collection | DOAJ |
| description | Abstract Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical manifestation that has the potential to cause severe oral and/or systemic diseases and compromise quality of life. Currently, the standard-of-care for this condition remains palliative. A variety of approaches have been employed to restore saliva production, but they have largely failed due to damage to both secretory cells and the extracellular matrix (niche). Transplantation of allogeneic cells from healthy donors has been suggested as a potential solution, but no definitive population of SG stem cells, capable of regenerating the gland, has been identified. Alternatively, mesenchymal stem cells (MSCs) are abundant, well characterized, and during SG development/homeostasis engage in signaling crosstalk with the SG epithelium. Further, the trans-differentiation potential of these cells and their ability to regenerate SG tissues have been demonstrated. However, recent findings suggest that the “immuno-privileged” status of allogeneic adult MSCs may not reflect their status post-transplantation. In contrast, autologous MSCs can be recovered from healthy tissues and do not present a challenge to the recipient’s immune system. With recent advances in our ability to expand MSCs in vitro on tissue-specific matrices, autologous MSCs may offer a new therapeutic paradigm for restoration of SG function. |
| first_indexed | 2024-04-09T12:51:42Z |
| format | Article |
| id | doaj.art-79efb586d9fc4313b4e6b71ac8a83b1b |
| institution | Directory Open Access Journal |
| issn | 2049-3169 |
| language | English |
| last_indexed | 2024-04-09T12:51:42Z |
| publishDate | 2023-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | International Journal of Oral Science |
| spelling | doaj.art-79efb586d9fc4313b4e6b71ac8a83b1b2023-05-14T11:10:31ZengNature Publishing GroupInternational Journal of Oral Science2049-31692023-05-0115111910.1038/s41368-023-00224-5Autologous mesenchymal stem cells offer a new paradigm for salivary gland regenerationMilos Marinkovic0Olivia N. Tran1Hanzhou Wang2Parveez Abdul-Azees3David D. Dean4Xiao-Dong Chen5Chih-Ko Yeh6Department of Comprehensive Dentistry, University of Texas Health Science Center at San AntonioDepartment of Comprehensive Dentistry, University of Texas Health Science Center at San AntonioDepartment of Comprehensive Dentistry, University of Texas Health Science Center at San AntonioDepartment of Comprehensive Dentistry, University of Texas Health Science Center at San AntonioDepartment of Comprehensive Dentistry, University of Texas Health Science Center at San AntonioDepartment of Comprehensive Dentistry, University of Texas Health Science Center at San AntonioDepartment of Comprehensive Dentistry, University of Texas Health Science Center at San AntonioAbstract Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical manifestation that has the potential to cause severe oral and/or systemic diseases and compromise quality of life. Currently, the standard-of-care for this condition remains palliative. A variety of approaches have been employed to restore saliva production, but they have largely failed due to damage to both secretory cells and the extracellular matrix (niche). Transplantation of allogeneic cells from healthy donors has been suggested as a potential solution, but no definitive population of SG stem cells, capable of regenerating the gland, has been identified. Alternatively, mesenchymal stem cells (MSCs) are abundant, well characterized, and during SG development/homeostasis engage in signaling crosstalk with the SG epithelium. Further, the trans-differentiation potential of these cells and their ability to regenerate SG tissues have been demonstrated. However, recent findings suggest that the “immuno-privileged” status of allogeneic adult MSCs may not reflect their status post-transplantation. In contrast, autologous MSCs can be recovered from healthy tissues and do not present a challenge to the recipient’s immune system. With recent advances in our ability to expand MSCs in vitro on tissue-specific matrices, autologous MSCs may offer a new therapeutic paradigm for restoration of SG function.https://doi.org/10.1038/s41368-023-00224-5 |
| spellingShingle | Milos Marinkovic Olivia N. Tran Hanzhou Wang Parveez Abdul-Azees David D. Dean Xiao-Dong Chen Chih-Ko Yeh Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration International Journal of Oral Science |
| title | Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration |
| title_full | Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration |
| title_fullStr | Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration |
| title_full_unstemmed | Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration |
| title_short | Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration |
| title_sort | autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration |
| url | https://doi.org/10.1038/s41368-023-00224-5 |
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