Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection

Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection

It is intriguing that, unlike adults with HIV-1, children with HIV-1 reach a greater CD4+ T cell recovery following planned treatment cessation. The reasons for the better outcomes in children remain unknown but may be related to increased thymic output and diversity of T cell receptor repertoires....

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Bibliographic Details
Main Authors: Katrine Schou Sandgaard, Ben Margetts, Teresa Attenborough, Triantafylia Gkouleli, Stuart Adams, Mette Holm, Diana Gibb, Deena Gibbons, Carlo Giaquinto, Anita De Rossi, Alasdair Bamford, Paolo Palma, Benny Chain, Athina S. Gkazi, Nigel Klein
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
HIV-1
T cells
thymic output
antiretroviral treatment interruption
T cell receptor
immune repertoires
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.643189/full

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