LncRNA SOX2‐OT regulates AKT/ERK and SOX2/GLI‐1 expression, hinders therapy, and worsens clinical prognosis in malignant lung diseases

LncRNA SOX2‐OT regulates AKT/ERK and SOX2/GLI‐1 expression, hinders therapy, and worsens clinical prognosis in malignant lung diseases

The involvement of LncRNA SOX2‐overlapping transcript (SOX2‐OT), SOX2, and GLI‐1 transcription factors in cancer has been well documented. Nonetheless, it is still unknown whether co‐expressed SOX2‐OT/SOX2 or SOX2‐OT/SOX2/GLI‐1 axes are epigenetically/transcriptionally involved in terms of resistanc...

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Bibliographic Details
Main Authors: Abril Marcela Herrera‐Solorio, Irlanda Peralta‐Arrieta, Leonel Armas López, Nallely Hernández‐Cigala, Criselda Mendoza Milla, Blanca Ortiz Quintero, Rodrigo Catalán Cárdenas, Priscila Pineda Villegas, Evelyn Rodríguez Villanueva, Cynthia G. Trejo Iriarte, Joaquín Zúñiga, Oscar Arrieta, Federico Ávila‐Moreno
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Molecular Oncology
Subjects:
drug resistance
GLI‐1
LncRNA
lung adenocarcinoma
SOX2
SOX2‐OT
Online Access:https://doi.org/10.1002/1878-0261.12875

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