The Effects of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Erythropoietin, and Their Interactions in Angiogenesis: Implications in Retinopathy of Prematurity
Retinopathy of prematurity (ROP) is a leading cause of vision impairment and blindness in premature infants. Oxidative stress is implicated in its pathophysiology. NADPH oxidase (NOX), a major enzyme responsible for reactive oxygen species (ROS) generation in endothelial cells, has been studied for...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/12/1951 |
| _version_ | 1797488922568163328 |
|---|---|
| author | Thaonhi Cung Haibo Wang M. Elizabeth Hartnett |
| author_facet | Thaonhi Cung Haibo Wang M. Elizabeth Hartnett |
| author_sort | Thaonhi Cung |
| collection | DOAJ |
| description | Retinopathy of prematurity (ROP) is a leading cause of vision impairment and blindness in premature infants. Oxidative stress is implicated in its pathophysiology. NADPH oxidase (NOX), a major enzyme responsible for reactive oxygen species (ROS) generation in endothelial cells, has been studied for its involvement in physiologic and pathologic angiogenesis. Erythropoietin (EPO) has gained interest recently due to its tissue protective and angiogenic effects, and it has been shown to act as an antioxidant. In this review, we summarize studies performed over the last five years regarding the role of various NOXs in physiologic and pathologic angiogenesis. We also discuss the effect of EPO in tissue and vasoprotection, and the intersection of EPO and NOX-mediated oxidative stress in angiogenesis and the pathophysiology of ROP. |
| first_indexed | 2024-03-10T00:10:09Z |
| format | Article |
| id | doaj.art-79f51923646a484da6128c2e411f7593 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:10:09Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-79f51923646a484da6128c2e411f75932023-11-23T16:02:04ZengMDPI AGCells2073-44092022-06-011112195110.3390/cells11121951The Effects of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Erythropoietin, and Their Interactions in Angiogenesis: Implications in Retinopathy of PrematurityThaonhi Cung0Haibo Wang1M. Elizabeth Hartnett2Department of Ophthalmology, John A. Moran Eye Center, University of Utah, 65 Mario Capecchi Dr., Salt Lake City, UT 84132, USADepartment of Ophthalmology, John A. Moran Eye Center, University of Utah, 65 Mario Capecchi Dr., Salt Lake City, UT 84132, USADepartment of Ophthalmology, John A. Moran Eye Center, University of Utah, 65 Mario Capecchi Dr., Salt Lake City, UT 84132, USARetinopathy of prematurity (ROP) is a leading cause of vision impairment and blindness in premature infants. Oxidative stress is implicated in its pathophysiology. NADPH oxidase (NOX), a major enzyme responsible for reactive oxygen species (ROS) generation in endothelial cells, has been studied for its involvement in physiologic and pathologic angiogenesis. Erythropoietin (EPO) has gained interest recently due to its tissue protective and angiogenic effects, and it has been shown to act as an antioxidant. In this review, we summarize studies performed over the last five years regarding the role of various NOXs in physiologic and pathologic angiogenesis. We also discuss the effect of EPO in tissue and vasoprotection, and the intersection of EPO and NOX-mediated oxidative stress in angiogenesis and the pathophysiology of ROP.https://www.mdpi.com/2073-4409/11/12/1951ROPangiogenesisROSoxidative stressNADPH oxidaseNOX |
| spellingShingle | Thaonhi Cung Haibo Wang M. Elizabeth Hartnett The Effects of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Erythropoietin, and Their Interactions in Angiogenesis: Implications in Retinopathy of Prematurity Cells ROP angiogenesis ROS oxidative stress NADPH oxidase NOX |
| title | The Effects of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Erythropoietin, and Their Interactions in Angiogenesis: Implications in Retinopathy of Prematurity |
| title_full | The Effects of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Erythropoietin, and Their Interactions in Angiogenesis: Implications in Retinopathy of Prematurity |
| title_fullStr | The Effects of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Erythropoietin, and Their Interactions in Angiogenesis: Implications in Retinopathy of Prematurity |
| title_full_unstemmed | The Effects of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Erythropoietin, and Their Interactions in Angiogenesis: Implications in Retinopathy of Prematurity |
| title_short | The Effects of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Erythropoietin, and Their Interactions in Angiogenesis: Implications in Retinopathy of Prematurity |
| title_sort | effects of nicotinamide adenine dinucleotide phosphate nadph oxidase and erythropoietin and their interactions in angiogenesis implications in retinopathy of prematurity |
| topic | ROP angiogenesis ROS oxidative stress NADPH oxidase NOX |
| url | https://www.mdpi.com/2073-4409/11/12/1951 |
| work_keys_str_mv | AT thaonhicung theeffectsofnicotinamideadeninedinucleotidephosphatenadphoxidaseanderythropoietinandtheirinteractionsinangiogenesisimplicationsinretinopathyofprematurity AT haibowang theeffectsofnicotinamideadeninedinucleotidephosphatenadphoxidaseanderythropoietinandtheirinteractionsinangiogenesisimplicationsinretinopathyofprematurity AT melizabethhartnett theeffectsofnicotinamideadeninedinucleotidephosphatenadphoxidaseanderythropoietinandtheirinteractionsinangiogenesisimplicationsinretinopathyofprematurity AT thaonhicung effectsofnicotinamideadeninedinucleotidephosphatenadphoxidaseanderythropoietinandtheirinteractionsinangiogenesisimplicationsinretinopathyofprematurity AT haibowang effectsofnicotinamideadeninedinucleotidephosphatenadphoxidaseanderythropoietinandtheirinteractionsinangiogenesisimplicationsinretinopathyofprematurity AT melizabethhartnett effectsofnicotinamideadeninedinucleotidephosphatenadphoxidaseanderythropoietinandtheirinteractionsinangiogenesisimplicationsinretinopathyofprematurity |