Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in Cats
Congenital hypothyroidism is uncommon in cats. This case report describes weight gain, clinicopathological and radiographic changes after early diagnosis and treatment of congenital hypothyroidism in three British shorthair cats’ siblings. Data were assessed at 53 (diagnosis), 83, 185 and 365 days o...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/3/140 |
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| author | Stefania Golinelli Antonio Maria Tardo Carla Giuditta Vecchiato Eleonora Anicito Guido Simone Perfetti Alessia Diana Federico Fracassi |
| author_facet | Stefania Golinelli Antonio Maria Tardo Carla Giuditta Vecchiato Eleonora Anicito Guido Simone Perfetti Alessia Diana Federico Fracassi |
| author_sort | Stefania Golinelli |
| collection | DOAJ |
| description | Congenital hypothyroidism is uncommon in cats. This case report describes weight gain, clinicopathological and radiographic changes after early diagnosis and treatment of congenital hypothyroidism in three British shorthair cats’ siblings. Data were assessed at 53 (diagnosis), 83, 185 and 365 days of age. Correlations between serum insulin-like growth factor-1 (IGF-1) and body weight, levothyroxine dose, total thyroxine, and thyroid-stimulating hormone concentrations were evaluated. The body weights of the congenital hypothyroid kittens were compared with those of their two healthy siblings and British shorthair kittens of the same age. At diagnosis, the congenital hypothyroid kittens showed a significantly lower body weight compared to the healthy siblings (<i>p</i> = 0.03). After diagnosis, oral levothyroxine supplementation was started. The difference in body weight was no longer observed after one month of treatment. The clinical signs, clinicopathological and radiographic abnormalities ameliorated after one month of treatment. IGF-1 concentration was significantly positively correlated with body weight (rs = 0.80, <i>p</i> < 0.002). In conclusion, resolution of the clinical signs, achieving a consistent within-breed weight, and improvement of the clinicopathological and radiographic parameters demonstrated the importance of the early diagnosis and treatment of feline congenital hypothyroidism. |
| first_indexed | 2024-03-09T12:17:58Z |
| format | Article |
| id | doaj.art-79f5cd5e44b84a96822fc4a2cc52e8d3 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T12:17:58Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-79f5cd5e44b84a96822fc4a2cc52e8d32023-11-30T22:44:43ZengMDPI AGVeterinary Sciences2306-73812022-03-019314010.3390/vetsci9030140Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in CatsStefania Golinelli0Antonio Maria Tardo1Carla Giuditta Vecchiato2Eleonora Anicito Guido3Simone Perfetti4Alessia Diana5Federico Fracassi6Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia, 40064 Bologna, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia, 40064 Bologna, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia, 40064 Bologna, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia, 40064 Bologna, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia, 40064 Bologna, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia, 40064 Bologna, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia, 40064 Bologna, ItalyCongenital hypothyroidism is uncommon in cats. This case report describes weight gain, clinicopathological and radiographic changes after early diagnosis and treatment of congenital hypothyroidism in three British shorthair cats’ siblings. Data were assessed at 53 (diagnosis), 83, 185 and 365 days of age. Correlations between serum insulin-like growth factor-1 (IGF-1) and body weight, levothyroxine dose, total thyroxine, and thyroid-stimulating hormone concentrations were evaluated. The body weights of the congenital hypothyroid kittens were compared with those of their two healthy siblings and British shorthair kittens of the same age. At diagnosis, the congenital hypothyroid kittens showed a significantly lower body weight compared to the healthy siblings (<i>p</i> = 0.03). After diagnosis, oral levothyroxine supplementation was started. The difference in body weight was no longer observed after one month of treatment. The clinical signs, clinicopathological and radiographic abnormalities ameliorated after one month of treatment. IGF-1 concentration was significantly positively correlated with body weight (rs = 0.80, <i>p</i> < 0.002). In conclusion, resolution of the clinical signs, achieving a consistent within-breed weight, and improvement of the clinicopathological and radiographic parameters demonstrated the importance of the early diagnosis and treatment of feline congenital hypothyroidism.https://www.mdpi.com/2306-7381/9/3/140feline congenital hypothyroidismdwarfismlevothyroxine treatmentIGF-1 |
| spellingShingle | Stefania Golinelli Antonio Maria Tardo Carla Giuditta Vecchiato Eleonora Anicito Guido Simone Perfetti Alessia Diana Federico Fracassi Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in Cats Veterinary Sciences feline congenital hypothyroidism dwarfism levothyroxine treatment IGF-1 |
| title | Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in Cats |
| title_full | Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in Cats |
| title_fullStr | Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in Cats |
| title_full_unstemmed | Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in Cats |
| title_short | Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in Cats |
| title_sort | evaluation of weight gain clinicopathological and radiographic changes after early diagnosis and treatment of congenital hypothyroidism in cats |
| topic | feline congenital hypothyroidism dwarfism levothyroxine treatment IGF-1 |
| url | https://www.mdpi.com/2306-7381/9/3/140 |
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