The Lysyl Oxidase G473A Polymorphism Exacerbates Oral Cancer Development in Humans and Mice

The Lysyl Oxidase G473A Polymorphism Exacerbates Oral Cancer Development in Humans and Mice

Oral cancer is primarily squamous-cell carcinoma with a 5-year survival rate of approximately 50%. Lysyl oxidase (LOX) participates in collagen and elastin maturation. The propeptide of LOX is released as an 18 kDa protein (LOX-PP) in the extracellular environment by procollagen C-proteinases and ha...

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Bibliographic Details
Main Authors: Yaser Peymanfar, Faranak Mahjour, Neha Shrestha, Ana de la Cueva, Ying Chen, Shengyuan Huang, Kathrin H. Kirsch, Xiaozhe Han, Philip C. Trackman
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
oral cancer
polymorphism
lysyl oxidase
human
mouse model
4 NQO
Online Access:https://www.mdpi.com/1422-0067/24/11/9407

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