The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes
In the present study, we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide (PCP) on high-fat diet (HFD)-induced atherosclerosis in male and female LDLr−/− mice. Results showed that HFD caused severe dyslipidemia, atherosclerotic lesions, oxidative damages and i...
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Tsinghua University Press
2024-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023001179 |
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| author | Anjun Guo Xueying Li Lihua Pan Qiangming Li Jianping Luo Xueqiang Zha |
| author_facet | Anjun Guo Xueying Li Lihua Pan Qiangming Li Jianping Luo Xueqiang Zha |
| author_sort | Anjun Guo |
| collection | DOAJ |
| description | In the present study, we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide (PCP) on high-fat diet (HFD)-induced atherosclerosis in male and female LDLr−/− mice. Results showed that HFD caused severe dyslipidemia, atherosclerotic lesions, oxidative damages and inflammation in male and female mice, and these effects seemed to be more pronounced in males than in females. However, the above variations could be dose-dependently reversed by PCP treatment, and the intervention effects on males were greater than those on females. Nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPKs) and protein kinase B (Akt) are 3 pivotal signaling pathways mediating the development of atherosclerosis. Consistently, PCP was also found to significantly decrease the phosphorylation of p65, p38, extracellular-regulated kinase 1/2 (ERK1/2) and Akt, and increase the protein expression of inhibitor of NF-κB (IκB) in the aortas of male and female mice induced by HFD. Taken together, these findings indicated that PCP could be effective for the prevention of atherosclerosis, and the intervention effect of PCP on male mice was more obvious than that of female mice. |
| first_indexed | 2024-03-12T03:01:12Z |
| format | Article |
| id | doaj.art-79f94cda9cef42388d9647bd1cbc9575 |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T03:01:12Z |
| publishDate | 2024-01-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj.art-79f94cda9cef42388d9647bd1cbc95752023-09-03T14:44:17ZengTsinghua University PressFood Science and Human Wellness2213-45302024-01-01131370380The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexesAnjun Guo0Xueying Li1Lihua Pan2Qiangming Li3Jianping Luo4Xueqiang Zha5Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei 230009, China; School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, ChinaEngineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei 230009, China; School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, ChinaEngineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei 230009, ChinaEngineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei 230009, ChinaEngineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei 230009, China; School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, ChinaEngineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei 230009, China; School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China; Key Laboratory of Metabolism and Regulation for Major Disease of Anhui Higher Education Institutes, Hefei University of Technology, Hefei 230009, China; Corresponding author at: School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China.In the present study, we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide (PCP) on high-fat diet (HFD)-induced atherosclerosis in male and female LDLr−/− mice. Results showed that HFD caused severe dyslipidemia, atherosclerotic lesions, oxidative damages and inflammation in male and female mice, and these effects seemed to be more pronounced in males than in females. However, the above variations could be dose-dependently reversed by PCP treatment, and the intervention effects on males were greater than those on females. Nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPKs) and protein kinase B (Akt) are 3 pivotal signaling pathways mediating the development of atherosclerosis. Consistently, PCP was also found to significantly decrease the phosphorylation of p65, p38, extracellular-regulated kinase 1/2 (ERK1/2) and Akt, and increase the protein expression of inhibitor of NF-κB (IκB) in the aortas of male and female mice induced by HFD. Taken together, these findings indicated that PCP could be effective for the prevention of atherosclerosis, and the intervention effect of PCP on male mice was more obvious than that of female mice.http://www.sciencedirect.com/science/article/pii/S2213453023001179Polygonatum cyrtonema polysaccharideAnti-atherosclerosisSex |
| spellingShingle | Anjun Guo Xueying Li Lihua Pan Qiangming Li Jianping Luo Xueqiang Zha The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes Food Science and Human Wellness Polygonatum cyrtonema polysaccharide Anti-atherosclerosis Sex |
| title | The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes |
| title_full | The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes |
| title_fullStr | The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes |
| title_full_unstemmed | The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes |
| title_short | The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes |
| title_sort | interventional effect of polygonatum cyrtonema hua polysaccharide on atherosclerosis in mice of different sexes |
| topic | Polygonatum cyrtonema polysaccharide Anti-atherosclerosis Sex |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023001179 |
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