IL-22-Activated <i>MUC13</i> Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling

IL-22-Activated <i>MUC13</i> Impacts on Colonic Barrier Function through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling

Overexpression of the transmembrane mucin MUC13, as seen in inflammatory bowel diseases (IBD), could potentially impact barrier function. This study aimed to explore how inflammation-induced MUC13 disrupts epithelial barrier integrity by affecting junctional protein expression in IBD, thereby also c...

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Bibliographic Details
Main Authors: Tom Breugelmans, Wout Arras, Baptiste Oosterlinck, Aranzazu Jauregui-Amezaga, Michaël Somers, Bart Cuypers, Kris Laukens, Joris G. De Man, Heiko U. De Schepper, Benedicte Y. De Winter, Annemieke Smet
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
transmembrane mucin
tight junction
intracellular signaling
inflammation
Online Access:https://www.mdpi.com/2073-4409/12/9/1224

Internet

https://www.mdpi.com/2073-4409/12/9/1224

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