To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand Breaks

To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand Breaks

Early work by Muller and McClintock discovered that the physical ends of linear chromosomes, named telomeres, possess an inherent ability to escape unwarranted fusions. Since then, extensive research has shown that this special feature relies on specialized proteins and structural properties that co...

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Bibliographic Details
Main Authors: Erika Casari, Marco Gnugnoli, Carlo Rinaldi, Paolo Pizzul, Chiara Vittoria Colombo, Diego Bonetti, Maria Pia Longhese
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
telomere
double-strand breaks
checkpoint
senescence
<i>S. cerevisiae</i>
cancer
Online Access:https://www.mdpi.com/2073-4409/11/20/3224

Internet

https://www.mdpi.com/2073-4409/11/20/3224

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