Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and α,β-unsaturated ketone group

Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and α,β-unsaturated ketone group

A new series of tertiary amine derivatives of chlorochalcone (4a∼4l) were designed, synthesized and evaluated for the effect on acetylcholinesterase (AChE) and buthylcholinesterase (BuChE). The results indicated that all compounds revealed moderate or potent inhibitory activity against AChE, and som...

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Bibliographic Details
Main Authors: Xiao-hui Gao, Chao Zhou, Hao-ran Liu, Lin-bo Liu, Jing-jing Tang, Xin-hua Xia
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Acetylcholinesterase inhibitors
Alzheimer’s disease
chlorochalcones
pyrazoline
structure–activity relationship
Online Access:http://dx.doi.org/10.1080/14756366.2016.1243534

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