Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection.
We assessed viral co-infections in 155 patients with community-associated Clostridioides difficile infection in five U.S. sites during December 2012-February 2013. Eighteen patients (12%) tested positive for norovirus (n = 10), adenovirus (n = 4), rotavirus (n = 3), or sapovirus (n = 1). Co-infected...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0240549 |
| _version_ | 1818572084268236800 |
|---|---|
| author | Lauren Korhonen Jessica Cohen Nicole Gregoricus Monica M Farley Rebecca Perlmutter Stacy M Holzbauer Ghinwa Dumyati Zintars Beldavs Ashley Paulick Jan Vinjé Brandi M Limbago Fernanda C Lessa Alice Y Guh |
| author_facet | Lauren Korhonen Jessica Cohen Nicole Gregoricus Monica M Farley Rebecca Perlmutter Stacy M Holzbauer Ghinwa Dumyati Zintars Beldavs Ashley Paulick Jan Vinjé Brandi M Limbago Fernanda C Lessa Alice Y Guh |
| author_sort | Lauren Korhonen |
| collection | DOAJ |
| description | We assessed viral co-infections in 155 patients with community-associated Clostridioides difficile infection in five U.S. sites during December 2012-February 2013. Eighteen patients (12%) tested positive for norovirus (n = 10), adenovirus (n = 4), rotavirus (n = 3), or sapovirus (n = 1). Co-infected patients were more likely than non-co-infected patients to have nausea or vomiting (56% vs 31%; p = 0.04), suggesting that viral co-pathogens contributed to symptoms in some patients. There were no significant differences in prior healthcare or medication exposures or in CDI complications. |
| first_indexed | 2024-12-14T18:52:41Z |
| format | Article |
| id | doaj.art-79fe719476684e6aa6a96999850ebc9c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T18:52:41Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-79fe719476684e6aa6a96999850ebc9c2022-12-21T22:51:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011510e024054910.1371/journal.pone.0240549Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection.Lauren KorhonenJessica CohenNicole GregoricusMonica M FarleyRebecca PerlmutterStacy M HolzbauerGhinwa DumyatiZintars BeldavsAshley PaulickJan VinjéBrandi M LimbagoFernanda C LessaAlice Y GuhWe assessed viral co-infections in 155 patients with community-associated Clostridioides difficile infection in five U.S. sites during December 2012-February 2013. Eighteen patients (12%) tested positive for norovirus (n = 10), adenovirus (n = 4), rotavirus (n = 3), or sapovirus (n = 1). Co-infected patients were more likely than non-co-infected patients to have nausea or vomiting (56% vs 31%; p = 0.04), suggesting that viral co-pathogens contributed to symptoms in some patients. There were no significant differences in prior healthcare or medication exposures or in CDI complications.https://doi.org/10.1371/journal.pone.0240549 |
| spellingShingle | Lauren Korhonen Jessica Cohen Nicole Gregoricus Monica M Farley Rebecca Perlmutter Stacy M Holzbauer Ghinwa Dumyati Zintars Beldavs Ashley Paulick Jan Vinjé Brandi M Limbago Fernanda C Lessa Alice Y Guh Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection. PLoS ONE |
| title | Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection. |
| title_full | Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection. |
| title_fullStr | Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection. |
| title_full_unstemmed | Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection. |
| title_short | Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection. |
| title_sort | evaluation of viral co infections among patients with community associated clostridioides difficile infection |
| url | https://doi.org/10.1371/journal.pone.0240549 |
| work_keys_str_mv | AT laurenkorhonen evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT jessicacohen evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT nicolegregoricus evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT monicamfarley evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT rebeccaperlmutter evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT stacymholzbauer evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT ghinwadumyati evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT zintarsbeldavs evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT ashleypaulick evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT janvinje evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT brandimlimbago evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT fernandaclessa evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection AT aliceyguh evaluationofviralcoinfectionsamongpatientswithcommunityassociatedclostridioidesdifficileinfection |