Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk

Adiponectin, a hormone secreted by adipose tissue, plays a complex role in regulating metabolic homeostasis and has also garnered attention for its potential involvement in the pathogenesis of late-onset Alzheimer’s disease (LOAD). The objective of this study was to investigate the association of &l...

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Main Authors: Juraj Javor, Vladimíra Ďurmanová, Kristína Klučková, Zuzana Párnická, Dominika Radošinská, Stanislav Šutovský, Barbora Vašečková, Veronika Režnáková, Mária Králová, Karin Gmitterová, Štefan Zorad, Ivana Shawkatová
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Life
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Online Access:https://www.mdpi.com/2075-1729/14/3/346
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author Juraj Javor
Vladimíra Ďurmanová
Kristína Klučková
Zuzana Párnická
Dominika Radošinská
Stanislav Šutovský
Barbora Vašečková
Veronika Režnáková
Mária Králová
Karin Gmitterová
Štefan Zorad
Ivana Shawkatová
author_facet Juraj Javor
Vladimíra Ďurmanová
Kristína Klučková
Zuzana Párnická
Dominika Radošinská
Stanislav Šutovský
Barbora Vašečková
Veronika Režnáková
Mária Králová
Karin Gmitterová
Štefan Zorad
Ivana Shawkatová
author_sort Juraj Javor
collection DOAJ
description Adiponectin, a hormone secreted by adipose tissue, plays a complex role in regulating metabolic homeostasis and has also garnered attention for its potential involvement in the pathogenesis of late-onset Alzheimer’s disease (LOAD). The objective of this study was to investigate the association of <i>ADIPOQ</i> variants with plasma adiponectin levels and LOAD risk in subjects from the Slovak Caucasian population. For this purpose, 385 LOAD patients and 533 controls without cognitive impairment were recruited and genotyped for a total of eighteen <i>ADIPOQ</i> single nucleotide polymorphisms (SNPs). Both single-locus and haplotype-based logistic regression analyses were employed to assess the association of SNPs with LOAD risk, while linear regression analysis was used to explore their influence on adiponectin levels in LOAD patients. <i>ADIPOQ</i> variants rs822395 and rs2036373 in intron 1 were found to significantly elevate total adiponectin levels after accounting for several potential confounders. Additional SNPs in the 5′ region and intron 1 exhibited a non-significant trend of association with adiponectin. However, none of the <i>ADIPOQ</i> SNPs showed an association with LOAD risk, neither in the whole-group analysis nor in subgroup analyses after stratification for sex or the <i>APOE</i> ε4 allele, a well-established LOAD risk factor. In summary, while adiponectin has emerged as a potential contributor to the development of LOAD, this study did not unveil any significant involvement of its gene variants in susceptibility to the disease.
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spelling doaj.art-7a00708bb4324c24baeb223900fa213d2024-03-27T13:51:12ZengMDPI AGLife2075-17292024-03-0114334610.3390/life14030346Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease RiskJuraj Javor0Vladimíra Ďurmanová1Kristína Klučková2Zuzana Párnická3Dominika Radošinská4Stanislav Šutovský5Barbora Vašečková6Veronika Režnáková7Mária Králová8Karin Gmitterová9Štefan Zorad10Ivana Shawkatová11Institute of Immunology, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, SlovakiaInstitute of Immunology, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, SlovakiaClinic for Children and Adolescents, Faculty Hospital Nitra, 950 01 Nitra, SlovakiaInstitute of Immunology, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, SlovakiaInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, Slovakia1st Department of Neurology, Faculty of Medicine, Comenius University in Bratislava and University Hospital Bratislava, 813 69 Bratislava, SlovakiaDepartment of Psychiatry, Faculty of Medicine, Slovak Medical University in Bratislava and University Hospital Bratislava, 826 06 Bratislava, SlovakiaCare Center Centrum MEMORY, 851 03 Bratislava, SlovakiaDepartment of Psychiatry, Faculty of Medicine, Comenius University in Bratislava and University Hospital Bratislava, 813 69 Bratislava, Slovakia2nd Department of Neurology, Faculty of Medicine, Comenius University in Bratislava and University Hospital Bratislava, 833 05, Bratislava, SlovakiaInstitute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, 833 06 Bratislava, SlovakiaInstitute of Immunology, Faculty of Medicine, Comenius University in Bratislava, 811 08 Bratislava, SlovakiaAdiponectin, a hormone secreted by adipose tissue, plays a complex role in regulating metabolic homeostasis and has also garnered attention for its potential involvement in the pathogenesis of late-onset Alzheimer’s disease (LOAD). The objective of this study was to investigate the association of <i>ADIPOQ</i> variants with plasma adiponectin levels and LOAD risk in subjects from the Slovak Caucasian population. For this purpose, 385 LOAD patients and 533 controls without cognitive impairment were recruited and genotyped for a total of eighteen <i>ADIPOQ</i> single nucleotide polymorphisms (SNPs). Both single-locus and haplotype-based logistic regression analyses were employed to assess the association of SNPs with LOAD risk, while linear regression analysis was used to explore their influence on adiponectin levels in LOAD patients. <i>ADIPOQ</i> variants rs822395 and rs2036373 in intron 1 were found to significantly elevate total adiponectin levels after accounting for several potential confounders. Additional SNPs in the 5′ region and intron 1 exhibited a non-significant trend of association with adiponectin. However, none of the <i>ADIPOQ</i> SNPs showed an association with LOAD risk, neither in the whole-group analysis nor in subgroup analyses after stratification for sex or the <i>APOE</i> ε4 allele, a well-established LOAD risk factor. In summary, while adiponectin has emerged as a potential contributor to the development of LOAD, this study did not unveil any significant involvement of its gene variants in susceptibility to the disease.https://www.mdpi.com/2075-1729/14/3/346adiponectinAlzheimer’s diseaseassociation<i>ADIPOQ</i>single nucleotide polymorphismsusceptibility
spellingShingle Juraj Javor
Vladimíra Ďurmanová
Kristína Klučková
Zuzana Párnická
Dominika Radošinská
Stanislav Šutovský
Barbora Vašečková
Veronika Režnáková
Mária Králová
Karin Gmitterová
Štefan Zorad
Ivana Shawkatová
Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk
Life
adiponectin
Alzheimer’s disease
association
<i>ADIPOQ</i>
single nucleotide polymorphism
susceptibility
title Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk
title_full Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk
title_fullStr Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk
title_full_unstemmed Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk
title_short Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk
title_sort adiponectin gene polymorphisms a case control study on their role in late onset alzheimer s disease risk
topic adiponectin
Alzheimer’s disease
association
<i>ADIPOQ</i>
single nucleotide polymorphism
susceptibility
url https://www.mdpi.com/2075-1729/14/3/346
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