Postoperative radiotherapy may not be necessary for locally advanced head and neck squamous cell carcinoma: a case-match multicentre study
Abstract Background Some head and neck cancer surgeons found that many patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) without postoperative radiotherapy (PORT) also have a good prognosis. The purpose of this study was to determine the effect of PORT on survival in pa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-022-02288-x |
| _version_ | 1811334264149508096 |
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| author | Zhen-Hu Ren Jing-Shi Lei Zhi-Min Yang Sheng Zhang Jian-Jun Yu Han-Jiang Wu |
| author_facet | Zhen-Hu Ren Jing-Shi Lei Zhi-Min Yang Sheng Zhang Jian-Jun Yu Han-Jiang Wu |
| author_sort | Zhen-Hu Ren |
| collection | DOAJ |
| description | Abstract Background Some head and neck cancer surgeons found that many patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) without postoperative radiotherapy (PORT) also have a good prognosis. The purpose of this study was to determine the effect of PORT on survival in patients with LA-HNSCC. Methods A case-match cohort analysis was performed at two institutions on patients with LA-HNSCC. Patients who received surgery alone were case-matched 1: 1 with patients treated by surgery plus PORT based on pT, pN, tumor subsite etc. Results 114 patients were matched into 57 pairs, with a median follow-up period of 40.2 months. No difference in overall survival (OS, HR 0.88; 95% CI 0.50–1.58; P = 0.79) or disease-specific survival (DFS, 0.86; 95% CI 0.50–1.50; P = 0.76) was observed with no PORT. Conclusions PORT isn’t necessary for patients with LA-HNSCC who are treated for the first time as long as the head and neck cancer surgeon adhere to appropriate surgical concepts. The indications of PORT for patients with LA-HNSCC need to be further discussed. |
| first_indexed | 2024-04-13T17:05:12Z |
| format | Article |
| id | doaj.art-7a009dc181874a16b67aca4ac82ac883 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-13T17:05:12Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-7a009dc181874a16b67aca4ac82ac8832022-12-22T02:38:29ZengBMCBMC Oral Health1472-68312022-06-012211910.1186/s12903-022-02288-xPostoperative radiotherapy may not be necessary for locally advanced head and neck squamous cell carcinoma: a case-match multicentre studyZhen-Hu Ren0Jing-Shi Lei1Zhi-Min Yang2Sheng Zhang3Jian-Jun Yu4Han-Jiang Wu5Department of Oral and Maxillofacial Surgery, Second Xiangya Hospital of Central South UniversityDepartment of Oral and Maxillofacial Surgery, Second Xiangya Hospital of Central South UniversityDepartment of Oral and Maxillofacial Surgery, Second Xiangya Hospital of Central South UniversityDepartment of Oral and Maxillofacial Surgery, Second Xiangya Hospital of Central South UniversityDepartment of Head and Neck Surgery, Hunan Cancer HospitalDepartment of Oral and Maxillofacial Surgery, Second Xiangya Hospital of Central South UniversityAbstract Background Some head and neck cancer surgeons found that many patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) without postoperative radiotherapy (PORT) also have a good prognosis. The purpose of this study was to determine the effect of PORT on survival in patients with LA-HNSCC. Methods A case-match cohort analysis was performed at two institutions on patients with LA-HNSCC. Patients who received surgery alone were case-matched 1: 1 with patients treated by surgery plus PORT based on pT, pN, tumor subsite etc. Results 114 patients were matched into 57 pairs, with a median follow-up period of 40.2 months. No difference in overall survival (OS, HR 0.88; 95% CI 0.50–1.58; P = 0.79) or disease-specific survival (DFS, 0.86; 95% CI 0.50–1.50; P = 0.76) was observed with no PORT. Conclusions PORT isn’t necessary for patients with LA-HNSCC who are treated for the first time as long as the head and neck cancer surgeon adhere to appropriate surgical concepts. The indications of PORT for patients with LA-HNSCC need to be further discussed.https://doi.org/10.1186/s12903-022-02288-xHead and neck squamous cell carcinomaPostoperative radiotherapySurgery aloneOverall survivalDisease-specific survival |
| spellingShingle | Zhen-Hu Ren Jing-Shi Lei Zhi-Min Yang Sheng Zhang Jian-Jun Yu Han-Jiang Wu Postoperative radiotherapy may not be necessary for locally advanced head and neck squamous cell carcinoma: a case-match multicentre study BMC Oral Health Head and neck squamous cell carcinoma Postoperative radiotherapy Surgery alone Overall survival Disease-specific survival |
| title | Postoperative radiotherapy may not be necessary for locally advanced head and neck squamous cell carcinoma: a case-match multicentre study |
| title_full | Postoperative radiotherapy may not be necessary for locally advanced head and neck squamous cell carcinoma: a case-match multicentre study |
| title_fullStr | Postoperative radiotherapy may not be necessary for locally advanced head and neck squamous cell carcinoma: a case-match multicentre study |
| title_full_unstemmed | Postoperative radiotherapy may not be necessary for locally advanced head and neck squamous cell carcinoma: a case-match multicentre study |
| title_short | Postoperative radiotherapy may not be necessary for locally advanced head and neck squamous cell carcinoma: a case-match multicentre study |
| title_sort | postoperative radiotherapy may not be necessary for locally advanced head and neck squamous cell carcinoma a case match multicentre study |
| topic | Head and neck squamous cell carcinoma Postoperative radiotherapy Surgery alone Overall survival Disease-specific survival |
| url | https://doi.org/10.1186/s12903-022-02288-x |
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