Dose–Effect Relationship Between Gastric Cancer and Common Digestive Tract Symptoms and Diagnoses in Anhui, China
Mengsha Tang,1 Xingrong Shen,2 Jing Chai,2 Jing Cheng,2 Debin Wang1,2 1School of Public Health, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2School of Health Service Management, Anhui Medical University, Hefei, Anhui, People’s Republic of ChinaCorresponden...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-06-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/doseeffect-relationship-between-gastric-cancer-and-common-digestive-tr-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1818835978688659456 |
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| author | Tang M Shen X Chai J Cheng J Wang D |
| author_facet | Tang M Shen X Chai J Cheng J Wang D |
| author_sort | Tang M |
| collection | DOAJ |
| description | Mengsha Tang,1 Xingrong Shen,2 Jing Chai,2 Jing Cheng,2 Debin Wang1,2 1School of Public Health, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2School of Health Service Management, Anhui Medical University, Hefei, Anhui, People’s Republic of ChinaCorrespondence: Debin Wang Tel/Fax +86-0551-65116395Email dbwang@vip.sina.comBackground: Early prevention and diagnosis are key to reducing the huge burden of gastric cancer (GC). Nearly half of the population worldwide are suffering from some form of digestive tract conditions (symptoms/diagnoses, DTCs) but their relations with GC are not well understood. We aim to explore the relationships (especially dose–effect relationships) between GC and DTCs.Methods: This study used data from a community-based case–control study in Anhui, China during 2016– 2019 and performed multivariate conditional logistic regression modeling of the associations between GC and DTCs.Results: A total of 2255 participants (451 cases and 1804 controls) completed the study. Statistically significant relations (P< 0.05) were found between GC and the presence of gastroesophageal reflux [odds ratio (OR)=1.41], odynophagia (OR=1.87), stomach discomfort (OR=1.86), poor appetite (OR=2.01) and Helicobacter pylori (H. pylori) infection (OR=4.39). When the DTCs were divided into duration grades, all these ORs presented an increasing trend (P< 0.05), being 1.89 to 2.45 for gastroesophageal reflux, 1.63 to 3.78 for stomach discomfort, 2.36 to 5.29 for poor appetite, and 3.95 to 10.03 for H. pylori infection. When the DTCs were divided into severity grades, the ORs also witnessed an increasing trend (P< 0.05), being 1.69 to 2.52 for gastroesophageal reflux, 2.44 to 3.56 for stomach discomfort, and 2.22 to 2.75 for poor appetite. When the DTCs were divided into duration-severity grades, the ORs displayed a much steeper increasing trend, being 0.49 to 4.96 for gastroesophageal reflux, 1.50 to 6.33 for odynophagia, 0.47 to 3.32 for stomach discomfort, and 0.40 to 10.47 for poor appetite. In contrast, the ORs for the lower DTCs were generally tested without statistical significance.Conclusion: The study revealed consistent dose–effect associations between GC and duration of gastroesophageal reflux, stomach discomfort, poor appetite, and H. pylori infection; severity of gastroesophageal reflux, stomach discomfort and poor appetite; and duration-severity of gastroesophageal reflux, odynophagia, stomach discomfort and poor appetite. These should inform future prevention, diagnosis and further research in patients with GC.Keywords: gastric cancer, digestive tract, symptoms, case–control study, dose–effect relations |
| first_indexed | 2024-12-19T02:59:18Z |
| format | Article |
| id | doaj.art-7a00c9844c7f43b79cd826f3c3ded931 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-19T02:59:18Z |
| publishDate | 2021-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-7a00c9844c7f43b79cd826f3c3ded9312022-12-21T20:38:16ZengDove Medical PressCancer Management and Research1179-13222021-06-01Volume 134955496666144Dose–Effect Relationship Between Gastric Cancer and Common Digestive Tract Symptoms and Diagnoses in Anhui, ChinaTang MShen XChai JCheng JWang DMengsha Tang,1 Xingrong Shen,2 Jing Chai,2 Jing Cheng,2 Debin Wang1,2 1School of Public Health, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2School of Health Service Management, Anhui Medical University, Hefei, Anhui, People’s Republic of ChinaCorrespondence: Debin Wang Tel/Fax +86-0551-65116395Email dbwang@vip.sina.comBackground: Early prevention and diagnosis are key to reducing the huge burden of gastric cancer (GC). Nearly half of the population worldwide are suffering from some form of digestive tract conditions (symptoms/diagnoses, DTCs) but their relations with GC are not well understood. We aim to explore the relationships (especially dose–effect relationships) between GC and DTCs.Methods: This study used data from a community-based case–control study in Anhui, China during 2016– 2019 and performed multivariate conditional logistic regression modeling of the associations between GC and DTCs.Results: A total of 2255 participants (451 cases and 1804 controls) completed the study. Statistically significant relations (P< 0.05) were found between GC and the presence of gastroesophageal reflux [odds ratio (OR)=1.41], odynophagia (OR=1.87), stomach discomfort (OR=1.86), poor appetite (OR=2.01) and Helicobacter pylori (H. pylori) infection (OR=4.39). When the DTCs were divided into duration grades, all these ORs presented an increasing trend (P< 0.05), being 1.89 to 2.45 for gastroesophageal reflux, 1.63 to 3.78 for stomach discomfort, 2.36 to 5.29 for poor appetite, and 3.95 to 10.03 for H. pylori infection. When the DTCs were divided into severity grades, the ORs also witnessed an increasing trend (P< 0.05), being 1.69 to 2.52 for gastroesophageal reflux, 2.44 to 3.56 for stomach discomfort, and 2.22 to 2.75 for poor appetite. When the DTCs were divided into duration-severity grades, the ORs displayed a much steeper increasing trend, being 0.49 to 4.96 for gastroesophageal reflux, 1.50 to 6.33 for odynophagia, 0.47 to 3.32 for stomach discomfort, and 0.40 to 10.47 for poor appetite. In contrast, the ORs for the lower DTCs were generally tested without statistical significance.Conclusion: The study revealed consistent dose–effect associations between GC and duration of gastroesophageal reflux, stomach discomfort, poor appetite, and H. pylori infection; severity of gastroesophageal reflux, stomach discomfort and poor appetite; and duration-severity of gastroesophageal reflux, odynophagia, stomach discomfort and poor appetite. These should inform future prevention, diagnosis and further research in patients with GC.Keywords: gastric cancer, digestive tract, symptoms, case–control study, dose–effect relationshttps://www.dovepress.com/doseeffect-relationship-between-gastric-cancer-and-common-digestive-tr-peer-reviewed-fulltext-article-CMARgastric cancerdigestive tractsymptomscase-control studydose-effect relations |
| spellingShingle | Tang M Shen X Chai J Cheng J Wang D Dose–Effect Relationship Between Gastric Cancer and Common Digestive Tract Symptoms and Diagnoses in Anhui, China Cancer Management and Research gastric cancer digestive tract symptoms case-control study dose-effect relations |
| title | Dose–Effect Relationship Between Gastric Cancer and Common Digestive Tract Symptoms and Diagnoses in Anhui, China |
| title_full | Dose–Effect Relationship Between Gastric Cancer and Common Digestive Tract Symptoms and Diagnoses in Anhui, China |
| title_fullStr | Dose–Effect Relationship Between Gastric Cancer and Common Digestive Tract Symptoms and Diagnoses in Anhui, China |
| title_full_unstemmed | Dose–Effect Relationship Between Gastric Cancer and Common Digestive Tract Symptoms and Diagnoses in Anhui, China |
| title_short | Dose–Effect Relationship Between Gastric Cancer and Common Digestive Tract Symptoms and Diagnoses in Anhui, China |
| title_sort | dose ndash effect relationship between gastric cancer and common digestive tract symptoms and diagnoses in anhui china |
| topic | gastric cancer digestive tract symptoms case-control study dose-effect relations |
| url | https://www.dovepress.com/doseeffect-relationship-between-gastric-cancer-and-common-digestive-tr-peer-reviewed-fulltext-article-CMAR |
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