Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease
Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis. Accumulating evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver diseases. Impaired autophagy prevents the clea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2018-09-01
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| Series: | Liver Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542568418300199 |
| _version_ | 1830192281415581696 |
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| author | Bilon Khambu Shengmin Yan Nazmul Huda Gang Liu Xiao-Ming Yin |
| author_facet | Bilon Khambu Shengmin Yan Nazmul Huda Gang Liu Xiao-Ming Yin |
| author_sort | Bilon Khambu |
| collection | DOAJ |
| description | Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis. Accumulating evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver diseases. Impaired autophagy prevents the clearance of excessive lipid droplets (LDs), damaged mitochondria, and toxic protein aggregates, which can be generated during the progression of various liver diseases, thus contributing to the development of steatosis, injury, steatohepatitis, fibrosis, and tumors. In this review, we look at the status of hepatic autophagy during the pathogenesis of alcoholic and non-alcoholic liver diseases. We also examine the mechanisms of defects in autophagy, and the hepato-protective roles of autophagy in non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), focusing mainly on steatosis and liver injury. Finally, we discuss the therapeutic potential of autophagy modulating agents for the treatment of these two common liver diseases. Keywords: Autophagy, Non-alcoholic fatty liver disease (NAFLD), Alcoholic liver disease (ALD), Liver injury, Steatosis |
| first_indexed | 2024-12-17T23:53:50Z |
| format | Article |
| id | doaj.art-7a0136a2af2b41ce8dcd19d3de61988c |
| institution | Directory Open Access Journal |
| issn | 2542-5684 |
| language | English |
| last_indexed | 2024-12-17T23:53:50Z |
| publishDate | 2018-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Liver Research |
| spelling | doaj.art-7a0136a2af2b41ce8dcd19d3de61988c2022-12-21T21:28:08ZengKeAi Communications Co., Ltd.Liver Research2542-56842018-09-0123112119Autophagy in non-alcoholic fatty liver disease and alcoholic liver diseaseBilon Khambu0Shengmin Yan1Nazmul Huda2Gang Liu3Xiao-Ming Yin4Corresponding author.; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USADepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USADepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USADepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USADepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USAAutophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis. Accumulating evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver diseases. Impaired autophagy prevents the clearance of excessive lipid droplets (LDs), damaged mitochondria, and toxic protein aggregates, which can be generated during the progression of various liver diseases, thus contributing to the development of steatosis, injury, steatohepatitis, fibrosis, and tumors. In this review, we look at the status of hepatic autophagy during the pathogenesis of alcoholic and non-alcoholic liver diseases. We also examine the mechanisms of defects in autophagy, and the hepato-protective roles of autophagy in non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), focusing mainly on steatosis and liver injury. Finally, we discuss the therapeutic potential of autophagy modulating agents for the treatment of these two common liver diseases. Keywords: Autophagy, Non-alcoholic fatty liver disease (NAFLD), Alcoholic liver disease (ALD), Liver injury, Steatosishttp://www.sciencedirect.com/science/article/pii/S2542568418300199 |
| spellingShingle | Bilon Khambu Shengmin Yan Nazmul Huda Gang Liu Xiao-Ming Yin Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease Liver Research |
| title | Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease |
| title_full | Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease |
| title_fullStr | Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease |
| title_full_unstemmed | Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease |
| title_short | Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease |
| title_sort | autophagy in non alcoholic fatty liver disease and alcoholic liver disease |
| url | http://www.sciencedirect.com/science/article/pii/S2542568418300199 |
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