Interleukin‐38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2‐p38 pathway‐dependent manner

Interleukin‐38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2‐p38 pathway‐dependent manner

Abstract Macrophages play crucial roles in abdominal aortic aneurysm (AAA) formation through the inflammatory response and extracellular matrix degradation; therefore, regulating macrophages may suppress AAA formation. Interleukin‐38 (IL‐38) is a member of the IL‐1 family, which binds to IL‐36 recep...

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Bibliographic Details
Main Authors: Shun Kurose, Yutaka Matsubara, Shinichiro Yoshino, Keiji Yoshiya, Koichi Morisaki, Tadashi Furuyama, Tomoaki Hoshino, Tomoharu Yoshizumi
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Physiological Reports
Subjects:
abdominal aortic aneurysm
inflammation
Interleukin‐38
macrophage
Online Access:https://doi.org/10.14814/phy2.15581

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