Antarctic organisms as a source of antimicrobial compounds: a patent review
Abstract Currently, antimicrobial resistance has become a global public health problem, which has made the need for new antimicrobial compounds to deal with resistant infections an emergency. However, environments that once offered so many innovative molecules, now already exhaustively exploited, do...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2021-03-01
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| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000200909&lng=en&tlng=en |
| _version_ | 1811332030638587904 |
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| author | MAURÍCIO B. SILVA ALEXYA O. FEITOSA IGOR G.O. LIMA JAMES R.S. BISPO ANA CAROLINE M. SANTOS MAGNA S.A. MOREIRA PAULO E.A.S. CÂMARA LUIZ HENRIQUE ROSA VALÉRIA M. OLIVEIRA ALYSSON W.F. DUARTE ALINE C. QUEIROZ |
| author_facet | MAURÍCIO B. SILVA ALEXYA O. FEITOSA IGOR G.O. LIMA JAMES R.S. BISPO ANA CAROLINE M. SANTOS MAGNA S.A. MOREIRA PAULO E.A.S. CÂMARA LUIZ HENRIQUE ROSA VALÉRIA M. OLIVEIRA ALYSSON W.F. DUARTE ALINE C. QUEIROZ |
| author_sort | MAURÍCIO B. SILVA |
| collection | DOAJ |
| description | Abstract Currently, antimicrobial resistance has become a global public health problem, which has made the need for new antimicrobial compounds to deal with resistant infections an emergency. However, environments that once offered so many innovative molecules, now already exhaustively exploited, do not meet this need. In this context, a geographically isolated, under-explored and extreme environment, such as Antarctica, which holds organisms with unique physiological and biochemical characteristics, assumes great importance as a potential source of new compounds with antimicrobial activity. In this patent review, we investigate the state of technological development in the field of antimicrobial compounds obtained from Antarctic organisms, highlighting the main countries and researchers active in the field, the species utilized, the compounds obtained, and their possible therapeutic applications. As results, few patent documents were found, however they encompass a wide diversity of compounds and species, indicating a great antimicrobial potential present in Antarctic biota, including compounds active against the most important human pathogenic microorganisms, such as including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus spp. and multi-resistant Mycobacterium tuberculosis. Furthermore, due to the increasing trend in patent applications, a significant rise in the number of patents in this area is expected in the coming years. |
| first_indexed | 2024-04-13T16:30:39Z |
| format | Article |
| id | doaj.art-7a0231b6d4f84926ba2575489857c302 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-13T16:30:39Z |
| publishDate | 2021-03-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-7a0231b6d4f84926ba2575489857c3022022-12-22T02:39:36ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902021-03-0194suppl 110.1590/0001-3765202220210840Antarctic organisms as a source of antimicrobial compounds: a patent reviewMAURÍCIO B. SILVAhttps://orcid.org/0000-0002-9462-8768ALEXYA O. FEITOSAhttps://orcid.org/0000-0003-0552-5175IGOR G.O. LIMAhttps://orcid.org/0000-0002-0021-7985JAMES R.S. BISPOhttps://orcid.org/0000-0001-6074-4464ANA CAROLINE M. SANTOShttps://orcid.org/0000-0003-0280-6107MAGNA S.A. MOREIRAhttps://orcid.org/0000-0002-9979-1994PAULO E.A.S. CÂMARAhttps://orcid.org/0000-0002-3944-996XLUIZ HENRIQUE ROSAhttps://orcid.org/0000-0001-9749-5182VALÉRIA M. OLIVEIRAhttps://orcid.org/0000-0001-8817-4758ALYSSON W.F. DUARTEhttps://orcid.org/0000-0001-9626-7524ALINE C. QUEIROZhttps://orcid.org/0000-0002-6362-2726Abstract Currently, antimicrobial resistance has become a global public health problem, which has made the need for new antimicrobial compounds to deal with resistant infections an emergency. However, environments that once offered so many innovative molecules, now already exhaustively exploited, do not meet this need. In this context, a geographically isolated, under-explored and extreme environment, such as Antarctica, which holds organisms with unique physiological and biochemical characteristics, assumes great importance as a potential source of new compounds with antimicrobial activity. In this patent review, we investigate the state of technological development in the field of antimicrobial compounds obtained from Antarctic organisms, highlighting the main countries and researchers active in the field, the species utilized, the compounds obtained, and their possible therapeutic applications. As results, few patent documents were found, however they encompass a wide diversity of compounds and species, indicating a great antimicrobial potential present in Antarctic biota, including compounds active against the most important human pathogenic microorganisms, such as including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus spp. and multi-resistant Mycobacterium tuberculosis. Furthermore, due to the increasing trend in patent applications, a significant rise in the number of patents in this area is expected in the coming years.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000200909&lng=en&tlng=enAntarcticaantimicrobial activityantimicrobial resistancenatural antimicrobialssecondary metabolites |
| spellingShingle | MAURÍCIO B. SILVA ALEXYA O. FEITOSA IGOR G.O. LIMA JAMES R.S. BISPO ANA CAROLINE M. SANTOS MAGNA S.A. MOREIRA PAULO E.A.S. CÂMARA LUIZ HENRIQUE ROSA VALÉRIA M. OLIVEIRA ALYSSON W.F. DUARTE ALINE C. QUEIROZ Antarctic organisms as a source of antimicrobial compounds: a patent review Anais da Academia Brasileira de Ciências Antarctica antimicrobial activity antimicrobial resistance natural antimicrobials secondary metabolites |
| title | Antarctic organisms as a source of antimicrobial compounds: a patent review |
| title_full | Antarctic organisms as a source of antimicrobial compounds: a patent review |
| title_fullStr | Antarctic organisms as a source of antimicrobial compounds: a patent review |
| title_full_unstemmed | Antarctic organisms as a source of antimicrobial compounds: a patent review |
| title_short | Antarctic organisms as a source of antimicrobial compounds: a patent review |
| title_sort | antarctic organisms as a source of antimicrobial compounds a patent review |
| topic | Antarctica antimicrobial activity antimicrobial resistance natural antimicrobials secondary metabolites |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000200909&lng=en&tlng=en |
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