Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity
Purpose: To assess the feasibility of imaging extremely low birth weight infants, defined as infants born weighing less than 1000 g or before 27 weeks of gestational age, with an arm-mounted optical coherence tomography angiography (OCTA) device. Methods: Cross-sectional case series conducted at a s...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993620300207 |
| _version_ | 1818113311930056704 |
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| author | Nikisha Kothari Alison Chu Jason Mingyi Huang Fei Lin Benjamin Ray Lin Niranjan Manoharan Wei Gui Alex S. Huang Irena Tsui |
| author_facet | Nikisha Kothari Alison Chu Jason Mingyi Huang Fei Lin Benjamin Ray Lin Niranjan Manoharan Wei Gui Alex S. Huang Irena Tsui |
| author_sort | Nikisha Kothari |
| collection | DOAJ |
| description | Purpose: To assess the feasibility of imaging extremely low birth weight infants, defined as infants born weighing less than 1000 g or before 27 weeks of gestational age, with an arm-mounted optical coherence tomography angiography (OCTA) device. Methods: Cross-sectional case series conducted at a single site in-patient academic center. Subjects included infants who had been born premature and met ROP screening criteria. Birth history such as gestational age and birth weight were collected. Subjects were imaged with OCTA in a supine position during ROP screening and treatment. Segmental errors were manually corrected and FAZ area was calculated from the superficial and deep capillary plexus (SCP, DCP) layers. Main outcomes measures were foveal avascular zone (FAZ) area, ROP stage and treatment. Results: Seven ELBW infants were included with an average gestational age of 25 weeks (range = 23-4/7 to 26 weeks) and average postmenstrual age of 54.7 weeks (range = 43–80 weeks) at the time of imaging. Average birth weight was 615 g (range 500–680 grams). Thirteen eyes had ROP treatment including primary laser, anti-vascular endothelial growth factor injection with delayed laser, and scleral buckle. Six infants were imaged under general anesthesia and one infant was imaged without sedation. Average FAZ area was 0.17 mm2 (range = 0.03 mm2–0.37 mm2) in the SCP and 0.04 mm2 (range 0 mm2–0.09 mm2) in the DCP. FAZ area correlated positively to the ratio of outer retinal layer thickness to inner retinal layer thickness at the foveal center in the SCP and DCP (r2 = 0.48, p = 0.02; r2 = 0.46, p = 0.02) and negatively with inner retinal layer thickness in the SCP (r2 = 0.56, p = 0.008). Conclusions and Importance: Arm-mounted OCTA was feasible in ELBW infants and provided information about the developing fovea. Measurement of FAZ area and retinal thickness using this modality may be used to study the effects of ELBW, peripheral ROP and ROP treatment on foveal development. |
| first_indexed | 2024-12-11T03:32:49Z |
| format | Article |
| id | doaj.art-7a02704ec07e4104987e078ce8b12f47 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-11T03:32:49Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-7a02704ec07e4104987e078ce8b12f472022-12-22T01:22:21ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362020-06-0118Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurityNikisha Kothari0Alison Chu1Jason Mingyi Huang2Fei Lin3Benjamin Ray Lin4Niranjan Manoharan5Wei Gui6Alex S. Huang7Irena Tsui8Department of Ophthalmology, Stein Eye Institute, Doheny Eye Institute, University of California, Los Angeles, USADepartment of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, USADepartment of Ophthalmology, Stein Eye Institute, Doheny Eye Institute, University of California, Los Angeles, USADepartment of Ophthalmology, Stein Eye Institute, Doheny Eye Institute, University of California, Los Angeles, USADepartment of Ophthalmology, Stein Eye Institute, Doheny Eye Institute, University of California, Los Angeles, USADepartment of Ophthalmology, Stein Eye Institute, Doheny Eye Institute, University of California, Los Angeles, USADepartment of Ophthalmology, Stein Eye Institute, Doheny Eye Institute, University of California, Los Angeles, USADepartment of Ophthalmology, Stein Eye Institute, Doheny Eye Institute, University of California, Los Angeles, USADepartment of Ophthalmology, Stein Eye Institute, Doheny Eye Institute, University of California, Los Angeles, USA; Corresponding author. University of California, Los Angeles 100 Stein Plaza, Los Angeles, CA, 90095, USA.Purpose: To assess the feasibility of imaging extremely low birth weight infants, defined as infants born weighing less than 1000 g or before 27 weeks of gestational age, with an arm-mounted optical coherence tomography angiography (OCTA) device. Methods: Cross-sectional case series conducted at a single site in-patient academic center. Subjects included infants who had been born premature and met ROP screening criteria. Birth history such as gestational age and birth weight were collected. Subjects were imaged with OCTA in a supine position during ROP screening and treatment. Segmental errors were manually corrected and FAZ area was calculated from the superficial and deep capillary plexus (SCP, DCP) layers. Main outcomes measures were foveal avascular zone (FAZ) area, ROP stage and treatment. Results: Seven ELBW infants were included with an average gestational age of 25 weeks (range = 23-4/7 to 26 weeks) and average postmenstrual age of 54.7 weeks (range = 43–80 weeks) at the time of imaging. Average birth weight was 615 g (range 500–680 grams). Thirteen eyes had ROP treatment including primary laser, anti-vascular endothelial growth factor injection with delayed laser, and scleral buckle. Six infants were imaged under general anesthesia and one infant was imaged without sedation. Average FAZ area was 0.17 mm2 (range = 0.03 mm2–0.37 mm2) in the SCP and 0.04 mm2 (range 0 mm2–0.09 mm2) in the DCP. FAZ area correlated positively to the ratio of outer retinal layer thickness to inner retinal layer thickness at the foveal center in the SCP and DCP (r2 = 0.48, p = 0.02; r2 = 0.46, p = 0.02) and negatively with inner retinal layer thickness in the SCP (r2 = 0.56, p = 0.008). Conclusions and Importance: Arm-mounted OCTA was feasible in ELBW infants and provided information about the developing fovea. Measurement of FAZ area and retinal thickness using this modality may be used to study the effects of ELBW, peripheral ROP and ROP treatment on foveal development.http://www.sciencedirect.com/science/article/pii/S2451993620300207Extremely low birth weight infantFoveal avascular zoneOptical coherence tomography angiographyPediatric retinaRetinal thicknessRetinopathy of prematurity |
| spellingShingle | Nikisha Kothari Alison Chu Jason Mingyi Huang Fei Lin Benjamin Ray Lin Niranjan Manoharan Wei Gui Alex S. Huang Irena Tsui Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity American Journal of Ophthalmology Case Reports Extremely low birth weight infant Foveal avascular zone Optical coherence tomography angiography Pediatric retina Retinal thickness Retinopathy of prematurity |
| title | Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity |
| title_full | Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity |
| title_fullStr | Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity |
| title_full_unstemmed | Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity |
| title_short | Arm-mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity |
| title_sort | arm mounted optical coherence tomography angiography in extremely low birth weight neonates with retinopathy of prematurity |
| topic | Extremely low birth weight infant Foveal avascular zone Optical coherence tomography angiography Pediatric retina Retinal thickness Retinopathy of prematurity |
| url | http://www.sciencedirect.com/science/article/pii/S2451993620300207 |
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