Carbon Fiber-Reinforced PolyEtherEtherKetone (CFR-PEEK) Instrumentation in Degenerative Disease of Lumbar Spine: A Pilot Study
CFR-PEEK is gaining popularity in spinal oncological applications due to its reduction of imaging artifacts and radiation scattering compared with titanium, which allows for better oncological follow-up and efficacy of radiotherapy. We evaluated the use of these materials for the treatment of lumbar...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/7/872 |
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| author | Riccardo Ghermandi Giovanni Tosini Alberto Lorenzi Cristiana Griffoni Luigi La Barbera Marco Girolami Valerio Pipola Giovanni Barbanti Brodano Stefano Bandiera Silvia Terzi Giuseppe Tedesco Gisberto Evangelisti Annalisa Monetta Luigi Emanuele Noli Luigi Falzetti Alessandro Gasbarrini |
| author_facet | Riccardo Ghermandi Giovanni Tosini Alberto Lorenzi Cristiana Griffoni Luigi La Barbera Marco Girolami Valerio Pipola Giovanni Barbanti Brodano Stefano Bandiera Silvia Terzi Giuseppe Tedesco Gisberto Evangelisti Annalisa Monetta Luigi Emanuele Noli Luigi Falzetti Alessandro Gasbarrini |
| author_sort | Riccardo Ghermandi |
| collection | DOAJ |
| description | CFR-PEEK is gaining popularity in spinal oncological applications due to its reduction of imaging artifacts and radiation scattering compared with titanium, which allows for better oncological follow-up and efficacy of radiotherapy. We evaluated the use of these materials for the treatment of lumbar degenerative diseases (DDs) and considered the biomechanical potential of the carbon fiber in relation to its modulus of elasticity being similar to that of bone. Twenty-eight patients with DDs were treated using CRF-PEEK instrumentation. The clinical and radiographic outcomes were collected at a 12-month FU. Spinal fusion was evaluated in the CT scans using Brantigan scores, while the clinical outcomes were evaluated using VAS, SF-12, and EQ-5D scores. Out of the patients evaluated at the 12-month FU, 89% showed complete or almost certain fusion (Brantigan score D and E) and presented a significant improvement in all clinical parameters; the patients also presented VAS scores ranging from 6.81 ± 2.01 to 0.85 ± 1.32, EQ-5D scores ranging from 53.4 ± 19.3 to 85.0 ± 13.7, SF-12 physical component scores (PCSs) ranging from 29.35 ± 7.04 to 51.36 ± 9.75, and SF-12 mental component scores (MCSs) ranging from 39.89 ± 11.70 to 53.24 ± 9.24. No mechanical complications related to the implant were detected, and the patients reported a better tolerance of the instrumentation compared with titanium. No other series of patients affected by DD that was stabilized using carbon fiber implants have been reported in the literature. The results of this pilot study indicate the efficacy and safety of these implants and support their use also for spinal degenerative diseases. |
| first_indexed | 2024-03-11T01:17:40Z |
| format | Article |
| id | doaj.art-7a03c14ae7e74b75a76bb84c8b0839c3 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T01:17:40Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-7a03c14ae7e74b75a76bb84c8b0839c32023-11-18T18:22:31ZengMDPI AGBioengineering2306-53542023-07-0110787210.3390/bioengineering10070872Carbon Fiber-Reinforced PolyEtherEtherKetone (CFR-PEEK) Instrumentation in Degenerative Disease of Lumbar Spine: A Pilot StudyRiccardo Ghermandi0Giovanni Tosini1Alberto Lorenzi2Cristiana Griffoni3Luigi La Barbera4Marco Girolami5Valerio Pipola6Giovanni Barbanti Brodano7Stefano Bandiera8Silvia Terzi9Giuseppe Tedesco10Gisberto Evangelisti11Annalisa Monetta12Luigi Emanuele Noli13Luigi Falzetti14Alessandro Gasbarrini15Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyOrtopedia e Traumatologia 3 ad Indirizzo Chirurgia Vertebrale, AOU Città della Salute e della Scienza (Presidio CTO), 10126 Torino, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyLaboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, 20133 Milano, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyCFR-PEEK is gaining popularity in spinal oncological applications due to its reduction of imaging artifacts and radiation scattering compared with titanium, which allows for better oncological follow-up and efficacy of radiotherapy. We evaluated the use of these materials for the treatment of lumbar degenerative diseases (DDs) and considered the biomechanical potential of the carbon fiber in relation to its modulus of elasticity being similar to that of bone. Twenty-eight patients with DDs were treated using CRF-PEEK instrumentation. The clinical and radiographic outcomes were collected at a 12-month FU. Spinal fusion was evaluated in the CT scans using Brantigan scores, while the clinical outcomes were evaluated using VAS, SF-12, and EQ-5D scores. Out of the patients evaluated at the 12-month FU, 89% showed complete or almost certain fusion (Brantigan score D and E) and presented a significant improvement in all clinical parameters; the patients also presented VAS scores ranging from 6.81 ± 2.01 to 0.85 ± 1.32, EQ-5D scores ranging from 53.4 ± 19.3 to 85.0 ± 13.7, SF-12 physical component scores (PCSs) ranging from 29.35 ± 7.04 to 51.36 ± 9.75, and SF-12 mental component scores (MCSs) ranging from 39.89 ± 11.70 to 53.24 ± 9.24. No mechanical complications related to the implant were detected, and the patients reported a better tolerance of the instrumentation compared with titanium. No other series of patients affected by DD that was stabilized using carbon fiber implants have been reported in the literature. The results of this pilot study indicate the efficacy and safety of these implants and support their use also for spinal degenerative diseases.https://www.mdpi.com/2306-5354/10/7/872degenerative lumbar spine diseasecarbon fiberCRF-PEEKspine fusionspondylolisthesis |
| spellingShingle | Riccardo Ghermandi Giovanni Tosini Alberto Lorenzi Cristiana Griffoni Luigi La Barbera Marco Girolami Valerio Pipola Giovanni Barbanti Brodano Stefano Bandiera Silvia Terzi Giuseppe Tedesco Gisberto Evangelisti Annalisa Monetta Luigi Emanuele Noli Luigi Falzetti Alessandro Gasbarrini Carbon Fiber-Reinforced PolyEtherEtherKetone (CFR-PEEK) Instrumentation in Degenerative Disease of Lumbar Spine: A Pilot Study Bioengineering degenerative lumbar spine disease carbon fiber CRF-PEEK spine fusion spondylolisthesis |
| title | Carbon Fiber-Reinforced PolyEtherEtherKetone (CFR-PEEK) Instrumentation in Degenerative Disease of Lumbar Spine: A Pilot Study |
| title_full | Carbon Fiber-Reinforced PolyEtherEtherKetone (CFR-PEEK) Instrumentation in Degenerative Disease of Lumbar Spine: A Pilot Study |
| title_fullStr | Carbon Fiber-Reinforced PolyEtherEtherKetone (CFR-PEEK) Instrumentation in Degenerative Disease of Lumbar Spine: A Pilot Study |
| title_full_unstemmed | Carbon Fiber-Reinforced PolyEtherEtherKetone (CFR-PEEK) Instrumentation in Degenerative Disease of Lumbar Spine: A Pilot Study |
| title_short | Carbon Fiber-Reinforced PolyEtherEtherKetone (CFR-PEEK) Instrumentation in Degenerative Disease of Lumbar Spine: A Pilot Study |
| title_sort | carbon fiber reinforced polyetheretherketone cfr peek instrumentation in degenerative disease of lumbar spine a pilot study |
| topic | degenerative lumbar spine disease carbon fiber CRF-PEEK spine fusion spondylolisthesis |
| url | https://www.mdpi.com/2306-5354/10/7/872 |
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