Physical exercise modulates the microglial complement pathway in mice to relieve cortical circuitry deficits induced by mutant human TDP-43

Physical exercise modulates the microglial complement pathway in mice to relieve cortical circuitry deficits induced by mutant human TDP-43

Summary: The aggregation of TAR DNA binding protein 43 kDa (TDP-43) is related to different neurodegenerative diseases, which leads to microglial activation and neuronal loss. The molecular mechanism driving neuronal death by reactive microglia, however, has not been completely resolved. In this stu...

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Bibliographic Details
Main Authors: Ji-an Wei, Linglin Liu, Xichen Song, Bilian Lin, Jing Cui, Lanzhi Luo, Yuchu Liu, Shihua Li, Xiaojiang Li, Kwok-Fai So, Sen Yan, Li Zhang
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723002516

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