Partnership status and positive DNA methylation age acceleration across the adult lifespan in the UK
Although a significant body of research has shown that married people are healthier and live longer, empirical research on sex differences in the link between marital status and health suggests results are mixed. Moreover, the sex disparities in marital status and health relationships vary across ad...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | SSM: Population Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352827323002161 |
| _version_ | 1797429989332746240 |
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| author | Wen Wang Anna Dearman Yanchun Bao Meena Kumari |
| author_facet | Wen Wang Anna Dearman Yanchun Bao Meena Kumari |
| author_sort | Wen Wang |
| collection | DOAJ |
| description | Although a significant body of research has shown that married people are healthier and live longer, empirical research on sex differences in the link between marital status and health suggests results are mixed. Moreover, the sex disparities in marital status and health relationships vary across adulthood. The literature on partnership status and measures of ageing is largely focused on older age groups and is limited in its view of early adulthood. Data from waves 2 and 3 (2010–2012) of Understanding Society: UKHLS were used to examine the association of current partnership status with epigenetic age acceleration (AA) assessed with DNA methylation (DNAm) algorithms 'Phenoage' and ' DunedinPACE ' in 3492 participants (aged 16–97). Regression models were estimated separately for men and women, and further stratified by age groups.Divorced/separated and widowed people showed positive age acceleration compared to the married/cohabiting people (reference group). Some sex differences were apparent, especially, among the single and divorced/separated groups. Age differences were also apparent, for example in men, being single was negatively associated with DNAmAA in the youngest group, but positively in the oldest group compared to partnered counterparts.These findings illustrate the importance of partnerships on the ageing process, in particular marital change through divorce and widowhood for positive age acceleration in adults. For single groups, observations were heterogenous by age and sex. |
| first_indexed | 2024-03-09T09:21:14Z |
| format | Article |
| id | doaj.art-7a04daf9523541389c4012f110af4576 |
| institution | Directory Open Access Journal |
| issn | 2352-8273 |
| language | English |
| last_indexed | 2024-03-09T09:21:14Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | SSM: Population Health |
| spelling | doaj.art-7a04daf9523541389c4012f110af45762023-12-02T07:00:46ZengElsevierSSM: Population Health2352-82732023-12-0124101551Partnership status and positive DNA methylation age acceleration across the adult lifespan in the UKWen Wang0Anna Dearman1Yanchun Bao2Meena Kumari3Institute for Social and Economic Research, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UKInstitute for Social and Economic Research, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UKDepartment of Mathematics, University of Essex, Wivenhoe Park, Colchester, Essex, UKInstitute for Social and Economic Research, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK; Corresponding author.Although a significant body of research has shown that married people are healthier and live longer, empirical research on sex differences in the link between marital status and health suggests results are mixed. Moreover, the sex disparities in marital status and health relationships vary across adulthood. The literature on partnership status and measures of ageing is largely focused on older age groups and is limited in its view of early adulthood. Data from waves 2 and 3 (2010–2012) of Understanding Society: UKHLS were used to examine the association of current partnership status with epigenetic age acceleration (AA) assessed with DNA methylation (DNAm) algorithms 'Phenoage' and ' DunedinPACE ' in 3492 participants (aged 16–97). Regression models were estimated separately for men and women, and further stratified by age groups.Divorced/separated and widowed people showed positive age acceleration compared to the married/cohabiting people (reference group). Some sex differences were apparent, especially, among the single and divorced/separated groups. Age differences were also apparent, for example in men, being single was negatively associated with DNAmAA in the youngest group, but positively in the oldest group compared to partnered counterparts.These findings illustrate the importance of partnerships on the ageing process, in particular marital change through divorce and widowhood for positive age acceleration in adults. For single groups, observations were heterogenous by age and sex.http://www.sciencedirect.com/science/article/pii/S2352827323002161Partnership statusDNA methylationPhenoageDunedinPACESexAge |
| spellingShingle | Wen Wang Anna Dearman Yanchun Bao Meena Kumari Partnership status and positive DNA methylation age acceleration across the adult lifespan in the UK SSM: Population Health Partnership status DNA methylation Phenoage DunedinPACE Sex Age |
| title | Partnership status and positive DNA methylation age acceleration across the adult lifespan in the UK |
| title_full | Partnership status and positive DNA methylation age acceleration across the adult lifespan in the UK |
| title_fullStr | Partnership status and positive DNA methylation age acceleration across the adult lifespan in the UK |
| title_full_unstemmed | Partnership status and positive DNA methylation age acceleration across the adult lifespan in the UK |
| title_short | Partnership status and positive DNA methylation age acceleration across the adult lifespan in the UK |
| title_sort | partnership status and positive dna methylation age acceleration across the adult lifespan in the uk |
| topic | Partnership status DNA methylation Phenoage DunedinPACE Sex Age |
| url | http://www.sciencedirect.com/science/article/pii/S2352827323002161 |
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