Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer

Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer

Enhancers are critical regulatory elements in the genome that help orchestrate spatiotemporal patterns of gene expression during development and normal physiology. In cancer, enhancers are often rewired by various genetic and epigenetic mechanisms for the activation of oncogenes that lead to initiat...

Full description

Bibliographic Details
Main Authors: Michael W. Lewis, Kamila Wisniewska, Caitlin M. King, Shen Li, Alisha Coffey, Michael R. Kelly, Matthew J. Regner, Hector L. Franco
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
breast cancer
ovarian cancer
enhancer
eRNA
CRISPR-Cas9
dCas9-KRAB
Online Access:https://www.mdpi.com/2072-6694/14/7/1852

Similar Items

Similar Items