Changes in the intestinal microbiota as a risk factor for dyslipidemia, atherosclerosis and the role of probiotics in their prevention
The review presents an analysis of studies on the role of the intestinal microbiota and microbiome in lipid metabolism and the development of dyslipidemia, atherosclerosis and cardiovascular diseases. The role of the intestine as a metabolic organ with a multifactorial strain evolution, involved in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2020-10-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/46862/32014 |
| _version_ | 1818922935495163904 |
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| author | O. S. Oynotkinova E. L. Nikonov T. Y. Demidova A. P. Baranov E. V. Kryukov E. I. Dedov E. A. Karavashkina |
| author_facet | O. S. Oynotkinova E. L. Nikonov T. Y. Demidova A. P. Baranov E. V. Kryukov E. I. Dedov E. A. Karavashkina |
| author_sort | O. S. Oynotkinova |
| collection | DOAJ |
| description | The review presents an analysis of studies on the role of the intestinal microbiota and microbiome in lipid metabolism and the development of dyslipidemia, atherosclerosis and cardiovascular diseases. The role of the intestine as a metabolic organ with a multifactorial strain evolution, involved in lipid metabolism, cholesterol homeostasis and enterohepatic circulation is shown. The influence of microbial imbalance on the development of dyslipidemia and atherosclerosis is considered. Special attention is paid to preventive therapy with hypolipidemic probiotics. It is shown that the use of probiotics with hypolipidemic properties and consisting of a mixture of such strains asLactobacillus plantarumCECT7527, CET7528 and CECT7529, mixtures ofLactobacillus acidophilusLa-5,Bifidobacterium lactisBB-12,Bifidobacterium animalis lactisBB-12 contribute to reducing the level of LDL-C, CCS, TG, are safe and well tolerated, can be used as an adjuvant non-drug therapy in combination with hypolipidemic drugs for dyslipidemia, multifocal atherosclerosis. |
| first_indexed | 2024-12-20T02:01:27Z |
| format | Article |
| id | doaj.art-7a06b2b7ec794e05b913eb4ad3c8733b |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-20T02:01:27Z |
| publishDate | 2020-10-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-7a06b2b7ec794e05b913eb4ad3c8733b2022-12-21T19:57:18Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422020-10-019299410110.26442/00403660.2020.09.00078442451Changes in the intestinal microbiota as a risk factor for dyslipidemia, atherosclerosis and the role of probiotics in their preventionO. S. Oynotkinova0E. L. Nikonov1T. Y. Demidova2A. P. Baranov3E. V. Kryukov4E. I. Dedov5E. A. Karavashkina6Research Institute of the Organization of Health Care and Medical Management; Pirogov Russian National Research Medical University; Lomonosov Moscow State UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityPirogov Russian National Research Medical University; Lomonosov Moscow State UniversityBurdenko Main Military Clinical HospitalPirogov Russian National Research Medical UniversityPolyclinic No1The review presents an analysis of studies on the role of the intestinal microbiota and microbiome in lipid metabolism and the development of dyslipidemia, atherosclerosis and cardiovascular diseases. The role of the intestine as a metabolic organ with a multifactorial strain evolution, involved in lipid metabolism, cholesterol homeostasis and enterohepatic circulation is shown. The influence of microbial imbalance on the development of dyslipidemia and atherosclerosis is considered. Special attention is paid to preventive therapy with hypolipidemic probiotics. It is shown that the use of probiotics with hypolipidemic properties and consisting of a mixture of such strains asLactobacillus plantarumCECT7527, CET7528 and CECT7529, mixtures ofLactobacillus acidophilusLa-5,Bifidobacterium lactisBB-12,Bifidobacterium animalis lactisBB-12 contribute to reducing the level of LDL-C, CCS, TG, are safe and well tolerated, can be used as an adjuvant non-drug therapy in combination with hypolipidemic drugs for dyslipidemia, multifocal atherosclerosis.https://ter-arkhiv.ru/0040-3660/article/viewFile/46862/32014gut microbiotamicrobiomemetabolismlipid metabolismdyslipidemiaatherosclerosisprobiotic |
| spellingShingle | O. S. Oynotkinova E. L. Nikonov T. Y. Demidova A. P. Baranov E. V. Kryukov E. I. Dedov E. A. Karavashkina Changes in the intestinal microbiota as a risk factor for dyslipidemia, atherosclerosis and the role of probiotics in their prevention Терапевтический архив gut microbiota microbiome metabolism lipid metabolism dyslipidemia atherosclerosis probiotic |
| title | Changes in the intestinal microbiota as a risk factor for dyslipidemia, atherosclerosis and the role of probiotics in their prevention |
| title_full | Changes in the intestinal microbiota as a risk factor for dyslipidemia, atherosclerosis and the role of probiotics in their prevention |
| title_fullStr | Changes in the intestinal microbiota as a risk factor for dyslipidemia, atherosclerosis and the role of probiotics in their prevention |
| title_full_unstemmed | Changes in the intestinal microbiota as a risk factor for dyslipidemia, atherosclerosis and the role of probiotics in their prevention |
| title_short | Changes in the intestinal microbiota as a risk factor for dyslipidemia, atherosclerosis and the role of probiotics in their prevention |
| title_sort | changes in the intestinal microbiota as a risk factor for dyslipidemia atherosclerosis and the role of probiotics in their prevention |
| topic | gut microbiota microbiome metabolism lipid metabolism dyslipidemia atherosclerosis probiotic |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/46862/32014 |
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