DNA and histones impair the mechanical stability and lytic susceptibility of fibrin formed by staphylocoagulase

DNA and histones impair the mechanical stability and lytic susceptibility of fibrin formed by staphylocoagulase

BackgroundStaphylocoagulase (SCG) is a virulence factor of Staphylococcus aureus, one of the most lethal pathogens of our times. The complex of SCG with prothrombin (SCG/ProT) can clot fibrinogen, and SCG/ProT-induced fibrin and plasma clots have been described to show decreased mechanical and lytic...

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Bibliographic Details
Main Authors: Erzsébet Komorowicz, Veronika J. Farkas, László Szabó, Sophie Cherrington, Craig Thelwell, Krasimir Kolev
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
staphylocoagulase
fibrin
fibrinolysis
NET
histone
extracellular DNA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1233128/full

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