Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection
Topical administration of drugs is required for the treatment of parasitic diseases and insect infestations; therefore, fabrication of nanoscale drug carriers for effective insecticide topical delivery is needed. Here we report the enhanced immobilization of halloysite tubule nanoclay onto semiaquat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/9/1477 |
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| author | Naureen Rahman Faith Hannah Scott Yuri Lvov Anna Stavitskaya Farida Akhatova Svetlana Konnova Gӧlnur Fakhrullina Rawil Fakhrullin |
| author_facet | Naureen Rahman Faith Hannah Scott Yuri Lvov Anna Stavitskaya Farida Akhatova Svetlana Konnova Gӧlnur Fakhrullina Rawil Fakhrullin |
| author_sort | Naureen Rahman |
| collection | DOAJ |
| description | Topical administration of drugs is required for the treatment of parasitic diseases and insect infestations; therefore, fabrication of nanoscale drug carriers for effective insecticide topical delivery is needed. Here we report the enhanced immobilization of halloysite tubule nanoclay onto semiaquatic capybaras which have hydrophobic hair surfaces as compared to their close relatives, land-dwelling guinea pigs, and other agricultural livestock. The hair surface of mammals varies in hydrophobicity having a cortex surrounded by cuticles. Spontaneous 1–2 µm thick halloysite hair coverages on the semi-aquatic rodent capybara, non-aquatic rodent guinea pig, and farm goats were compared. The best coating was found for capybara due to the elevated 5 wt% wax content. As a result, we suggest hair pretreatment with diluted wax for enhanced nanoclay adsorption. The formation of a stable goat hair coverage with a 2–3 µm halloysite layer loaded with permethrin insecticide allowed for long-lasting anti-parasitic protection, enduring multiple rain wettings and washings. We expect that our technology will find applications in animal parasitosis protection and may be extended to prolonged human anti-lice treatment. |
| first_indexed | 2024-03-10T07:18:23Z |
| format | Article |
| id | doaj.art-7a071eab40284bc6885833ebb4533727 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T07:18:23Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7a071eab40284bc6885833ebb45337272023-11-22T14:48:20ZengMDPI AGPharmaceutics1999-49232021-09-01139147710.3390/pharmaceutics13091477Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice ProtectionNaureen Rahman0Faith Hannah Scott1Yuri Lvov2Anna Stavitskaya3Farida Akhatova4Svetlana Konnova5Gӧlnur Fakhrullina6Rawil Fakhrullin7Institute for Micromanufacturing and Biomedical Engineering Program, Louisiana Tech University, Ruston, LA 71272, USAInstitute for Micromanufacturing and Biomedical Engineering Program, Louisiana Tech University, Ruston, LA 71272, USAInstitute for Micromanufacturing and Biomedical Engineering Program, Louisiana Tech University, Ruston, LA 71272, USADepartment of Physical and Colloid Chemistry, Gubkin University, Leninsky Pr. 65, 119991 Moscow, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kreml urami 18, 420008 Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kreml urami 18, 420008 Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kreml urami 18, 420008 Kazan, Republic of Tatarstan, RussiaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kreml urami 18, 420008 Kazan, Republic of Tatarstan, RussiaTopical administration of drugs is required for the treatment of parasitic diseases and insect infestations; therefore, fabrication of nanoscale drug carriers for effective insecticide topical delivery is needed. Here we report the enhanced immobilization of halloysite tubule nanoclay onto semiaquatic capybaras which have hydrophobic hair surfaces as compared to their close relatives, land-dwelling guinea pigs, and other agricultural livestock. The hair surface of mammals varies in hydrophobicity having a cortex surrounded by cuticles. Spontaneous 1–2 µm thick halloysite hair coverages on the semi-aquatic rodent capybara, non-aquatic rodent guinea pig, and farm goats were compared. The best coating was found for capybara due to the elevated 5 wt% wax content. As a result, we suggest hair pretreatment with diluted wax for enhanced nanoclay adsorption. The formation of a stable goat hair coverage with a 2–3 µm halloysite layer loaded with permethrin insecticide allowed for long-lasting anti-parasitic protection, enduring multiple rain wettings and washings. We expect that our technology will find applications in animal parasitosis protection and may be extended to prolonged human anti-lice treatment.https://www.mdpi.com/1999-4923/13/9/1477hair surface engineeringtopical drug administrationantiparasitic formulationshalloysiteself-assemblycapybara |
| spellingShingle | Naureen Rahman Faith Hannah Scott Yuri Lvov Anna Stavitskaya Farida Akhatova Svetlana Konnova Gӧlnur Fakhrullina Rawil Fakhrullin Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection Pharmaceutics hair surface engineering topical drug administration antiparasitic formulations halloysite self-assembly capybara |
| title | Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection |
| title_full | Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection |
| title_fullStr | Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection |
| title_full_unstemmed | Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection |
| title_short | Clay Nanotube Immobilization on Animal Hair for Sustained Anti-Lice Protection |
| title_sort | clay nanotube immobilization on animal hair for sustained anti lice protection |
| topic | hair surface engineering topical drug administration antiparasitic formulations halloysite self-assembly capybara |
| url | https://www.mdpi.com/1999-4923/13/9/1477 |
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