Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients
Summary: Background: The main objective of the present study was to analyze both clinical characteristics and evolution during hospitalization of a cohort of patients admitted for COVID-19 pneumonia who were not vaccinated, or with a complete or incomplete vaccination schedule. Methods: This COVID-...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | EClinicalMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537022001833 |
| _version_ | 1818156855500734464 |
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| author | Jose Rafael Teran-Tinedo Jesus Gonzalez-Rubio Alberto Najera Andrea Castany-Faro Maria de las Nieves Contreras Isabel Maria Garcia Lourdes Lopez-Mellado Miguel Lorente-Gonzalez Patricia Perez-Garvin Galaxia Sacristan-Crespo Miguel Suarez-Ortiz Juan D Navarro-Lopez Lydia Jimenez-Diaz Pedro Landete |
| author_facet | Jose Rafael Teran-Tinedo Jesus Gonzalez-Rubio Alberto Najera Andrea Castany-Faro Maria de las Nieves Contreras Isabel Maria Garcia Lourdes Lopez-Mellado Miguel Lorente-Gonzalez Patricia Perez-Garvin Galaxia Sacristan-Crespo Miguel Suarez-Ortiz Juan D Navarro-Lopez Lydia Jimenez-Diaz Pedro Landete |
| author_sort | Jose Rafael Teran-Tinedo |
| collection | DOAJ |
| description | Summary: Background: The main objective of the present study was to analyze both clinical characteristics and evolution during hospitalization of a cohort of patients admitted for COVID-19 pneumonia who were not vaccinated, or with a complete or incomplete vaccination schedule. Methods: This COVID-19 specialized single-center cohort study of 1888 COVID-19 patients hospitalized at the “Enfermera Isabel Zendal” Emergencies Hospital (HEEIZ), Madrid (Spain) was performed between July 1 and September 30, 2021. It compared the results of 1327 hospitalized unvaccinated patients to 209 hospitalized fully vaccinated and 352 hospitalized partially vaccinated patients. The four different COVID-19 vaccines authorized in Spain during the time-period studied were: BNT162b2 (Pfizer); ChAdOx1 nCoV-19 (AstraZeneca), mRNA-1273 (Moderna); Ad26.COV2.S (Janssen). Findings: Hospitalized patients’ median age was 41 years (IQR 33–50) for the unvaccinated and 61 years (IQR 53–67) for the fully vaccinated ones. The main comorbidities were obesity, hypertension and diabetes mellitus. 20% of unvaccinated patients (266) required noninvasive respiratory care, as did 14% (51) of partially and 14% (30) of fully vaccinated; 6% (78) of the unvaccinated patients also needed invasive respiratory care, as did 5% (16) of partially and 11 (5%) fully vaccinated. Interpretation: Fully vaccinated patients were 84% (95% CI: 82–86%) less likely to be admitted to hospital, and protection rose for those aged <50 years. Once hospitalized, vaccinated patients displayed more protection against requiring respiratory care than unvaccinated ones, despite being older and having more comorbidities. No differences appeared for the four studied COVID-19 vaccines and complying with vaccination recommendations proved relevant. Funding: The research was funded by the “Plan Propio de Investigación” Program of the Castilla-La Mancha University /European Regional Development Fund (2021-GRIN-31,039). |
| first_indexed | 2024-12-11T15:04:56Z |
| format | Article |
| id | doaj.art-7a07a96bf0d542cdbb1f98bfa1c8e50a |
| institution | Directory Open Access Journal |
| issn | 2589-5370 |
| language | English |
| last_indexed | 2024-12-11T15:04:56Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj.art-7a07a96bf0d542cdbb1f98bfa1c8e50a2022-12-22T01:00:59ZengElsevierEClinicalMedicine2589-53702022-06-0148101453Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patientsJose Rafael Teran-Tinedo0Jesus Gonzalez-Rubio1Alberto Najera2Andrea Castany-Faro3Maria de las Nieves Contreras4Isabel Maria Garcia5Lourdes Lopez-Mellado6Miguel Lorente-Gonzalez7Patricia Perez-Garvin8Galaxia Sacristan-Crespo9Miguel Suarez-Ortiz10Juan D Navarro-Lopez11Lydia Jimenez-Diaz12Pedro Landete13Respiratory intermediate Care Unit, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, Spain; Pneumology Service, General Universitary Hospital “Gregorio Marañón”, Madrid, Spain; Universidad Complutense de Madrid, Madrid, SpainUniversity of Castilla-La Mancha, NeuroPhysiology & Behavior Lab, Centre for Regional Biomedical Reserch (CRIB), Faculty of Medicine of Albacete, SpainUniversity of Castilla-La Mancha, NeuroPhysiology & Behavior Lab, Centre for Regional Biomedical Reserch (CRIB), Faculty of Medicine of Albacete, Spain; Corresponding author at: Department of Medical Sciences, Faculty of Medicine of Albacete, University of Castilla-La Mancha, Albacete, Spain.Admission Service, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, SpainAdmission Service, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, SpainNursering Management, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, Spain; Pneumology Service. Hospital Universitario ''La Paz'', Madrid, SpainAdmission Service, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, SpainRespiratory intermediate Care Unit, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, SpainAdmission Service, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, SpainAdmission Service, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, SpainRespiratory intermediate Care Unit, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, SpainUniversity of Castilla-La Mancha, NeuroPhysiology & Behavior Lab, Centre for Regional Biomedical Reserch (CRIB), Faculty of Medicine of Ciudad Real, Spain; Corresponding author at: Department of Medical Sciences, Faculty of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.University of Castilla-La Mancha, NeuroPhysiology & Behavior Lab, Centre for Regional Biomedical Reserch (CRIB), Faculty of Medicine of Ciudad Real, Spain; Corresponding author at: Department of Medical Sciences, Faculty of Medicine of Ciudad Real, University of Castilla-La Mancha, Ciudad Real, Spain.Respiratory intermediate Care Unit, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, Spain; Department of Pneumology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain; Corresponding author at: Respiratory intermediate Care Unit, “Enfermera Isabel Zendal” Emergency Hospital, Madrid, Spain.Summary: Background: The main objective of the present study was to analyze both clinical characteristics and evolution during hospitalization of a cohort of patients admitted for COVID-19 pneumonia who were not vaccinated, or with a complete or incomplete vaccination schedule. Methods: This COVID-19 specialized single-center cohort study of 1888 COVID-19 patients hospitalized at the “Enfermera Isabel Zendal” Emergencies Hospital (HEEIZ), Madrid (Spain) was performed between July 1 and September 30, 2021. It compared the results of 1327 hospitalized unvaccinated patients to 209 hospitalized fully vaccinated and 352 hospitalized partially vaccinated patients. The four different COVID-19 vaccines authorized in Spain during the time-period studied were: BNT162b2 (Pfizer); ChAdOx1 nCoV-19 (AstraZeneca), mRNA-1273 (Moderna); Ad26.COV2.S (Janssen). Findings: Hospitalized patients’ median age was 41 years (IQR 33–50) for the unvaccinated and 61 years (IQR 53–67) for the fully vaccinated ones. The main comorbidities were obesity, hypertension and diabetes mellitus. 20% of unvaccinated patients (266) required noninvasive respiratory care, as did 14% (51) of partially and 14% (30) of fully vaccinated; 6% (78) of the unvaccinated patients also needed invasive respiratory care, as did 5% (16) of partially and 11 (5%) fully vaccinated. Interpretation: Fully vaccinated patients were 84% (95% CI: 82–86%) less likely to be admitted to hospital, and protection rose for those aged <50 years. Once hospitalized, vaccinated patients displayed more protection against requiring respiratory care than unvaccinated ones, despite being older and having more comorbidities. No differences appeared for the four studied COVID-19 vaccines and complying with vaccination recommendations proved relevant. Funding: The research was funded by the “Plan Propio de Investigación” Program of the Castilla-La Mancha University /European Regional Development Fund (2021-GRIN-31,039).http://www.sciencedirect.com/science/article/pii/S2589537022001833COVID-19VaccinesVaccinated patientsPfizerBNT162b2AstraZeneca |
| spellingShingle | Jose Rafael Teran-Tinedo Jesus Gonzalez-Rubio Alberto Najera Andrea Castany-Faro Maria de las Nieves Contreras Isabel Maria Garcia Lourdes Lopez-Mellado Miguel Lorente-Gonzalez Patricia Perez-Garvin Galaxia Sacristan-Crespo Miguel Suarez-Ortiz Juan D Navarro-Lopez Lydia Jimenez-Diaz Pedro Landete Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients EClinicalMedicine COVID-19 Vaccines Vaccinated patients Pfizer BNT162b2 AstraZeneca |
| title | Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients |
| title_full | Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients |
| title_fullStr | Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients |
| title_full_unstemmed | Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients |
| title_short | Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients |
| title_sort | clinical characteristics and respiratory care in hospitalized vaccinated sars cov 2 patients |
| topic | COVID-19 Vaccines Vaccinated patients Pfizer BNT162b2 AstraZeneca |
| url | http://www.sciencedirect.com/science/article/pii/S2589537022001833 |
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