Antibody glycosylation as a potential biomarker for chronic inflammatory autoimmune diseases
Glycosylation of immunoglobulins (Ig) is known to influence their effector functions in physiological and pathological conditions. Changes in the glycosylation pattern of immunoglobulin G and autoantibodies in various inflammatory autoimmune diseases have been studied for many years. However, despit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2016-12-01
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| Series: | AIMS Genetics |
| Subjects: | |
| Online Access: | http://www.aimspress.com/Genetics/article/1140/fulltext.html |
| _version_ | 1818948565107474432 |
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| author | Jasmin Knopf Mona HC Biermann Luis E Muñoz Martin Herrmann |
| author_facet | Jasmin Knopf Mona HC Biermann Luis E Muñoz Martin Herrmann |
| author_sort | Jasmin Knopf |
| collection | DOAJ |
| description | Glycosylation of immunoglobulins (Ig) is known to influence their effector functions in physiological and pathological conditions. Changes in the glycosylation pattern of immunoglobulin G and autoantibodies in various inflammatory autoimmune diseases have been studied for many years. However, despite extensive research, many questions are still elusive regarding the formation of such differentially glycosylated antibodies and alterations of glycosylation patterns in other immunoglobulin classes for example. Nevertheless, knowledge has been deepened greatly, especially in the field of rheumatoid arthritis. Changes of Ig glycosylation patterns have been shown to appear before onset of the disease and moreover can subject to treatment. In this review, we discuss the potential of detecting Ig glycosylation changes as biomarkers for disease activity or monitoring of patients with chronic inflammatory autoimmune diseases such as antiphospholipid syndrome, rheumatoid arthritis, systemic lupus erythematosus, ANCA-associated vasculitis and Henoch-Schönlein purpura. |
| first_indexed | 2024-12-20T08:48:49Z |
| format | Article |
| id | doaj.art-7a0853780a5a46a49e8e24f78018f350 |
| institution | Directory Open Access Journal |
| issn | 2377-1143 |
| language | English |
| last_indexed | 2024-12-20T08:48:49Z |
| publishDate | 2016-12-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Genetics |
| spelling | doaj.art-7a0853780a5a46a49e8e24f78018f3502022-12-21T19:46:10ZengAIMS PressAIMS Genetics2377-11432016-12-013428029110.3934/genet.2016.4.280genetics-03-00280Antibody glycosylation as a potential biomarker for chronic inflammatory autoimmune diseasesJasmin Knopf0Mona HC Biermann1Luis E Muñoz2Martin Herrmann3Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, 91054 Erlangen, Germany.Glycosylation of immunoglobulins (Ig) is known to influence their effector functions in physiological and pathological conditions. Changes in the glycosylation pattern of immunoglobulin G and autoantibodies in various inflammatory autoimmune diseases have been studied for many years. However, despite extensive research, many questions are still elusive regarding the formation of such differentially glycosylated antibodies and alterations of glycosylation patterns in other immunoglobulin classes for example. Nevertheless, knowledge has been deepened greatly, especially in the field of rheumatoid arthritis. Changes of Ig glycosylation patterns have been shown to appear before onset of the disease and moreover can subject to treatment. In this review, we discuss the potential of detecting Ig glycosylation changes as biomarkers for disease activity or monitoring of patients with chronic inflammatory autoimmune diseases such as antiphospholipid syndrome, rheumatoid arthritis, systemic lupus erythematosus, ANCA-associated vasculitis and Henoch-Schönlein purpura.http://www.aimspress.com/Genetics/article/1140/fulltext.htmlAntibodyGlycosylationAutoimmunityFucosylationSialylationGalactosylationSLERAAPSANCA-associated vasculitisHPSCryoglobulins |
| spellingShingle | Jasmin Knopf Mona HC Biermann Luis E Muñoz Martin Herrmann Antibody glycosylation as a potential biomarker for chronic inflammatory autoimmune diseases AIMS Genetics Antibody Glycosylation Autoimmunity Fucosylation Sialylation Galactosylation SLE RA APS ANCA-associated vasculitis HPS Cryoglobulins |
| title | Antibody glycosylation as a potential biomarker for chronic inflammatory autoimmune diseases |
| title_full | Antibody glycosylation as a potential biomarker for chronic inflammatory autoimmune diseases |
| title_fullStr | Antibody glycosylation as a potential biomarker for chronic inflammatory autoimmune diseases |
| title_full_unstemmed | Antibody glycosylation as a potential biomarker for chronic inflammatory autoimmune diseases |
| title_short | Antibody glycosylation as a potential biomarker for chronic inflammatory autoimmune diseases |
| title_sort | antibody glycosylation as a potential biomarker for chronic inflammatory autoimmune diseases |
| topic | Antibody Glycosylation Autoimmunity Fucosylation Sialylation Galactosylation SLE RA APS ANCA-associated vasculitis HPS Cryoglobulins |
| url | http://www.aimspress.com/Genetics/article/1140/fulltext.html |
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