Analysis of risk factors of lymph node metastasis and comparison of endoscopic resection methods in rectal neuroendocrine neoplasm
Background and purpose: In recent years, the incidence of rectal neuroendocrine neoplasm (R-NEN) has been on the rise. However, its treatment remains controversial, especially for tumors of 10-20 mm in diameter. In this study, the clinicopathological characteristics of R-NEN were analyzed, the risk...
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| Format: | Article |
| Language: | English |
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Editorial Office of China Oncology
2022-09-01
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| Series: | Zhongguo aizheng zazhi |
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| Online Access: | http://www.china-oncology.com/fileup/1007-3639/PDF/1666588252284-1289049405.pdf |
| _version_ | 1811192344960040960 |
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| author | ZHENG Xiuli, YAO Zhiyuan, WU Mingli, ER Limian, LI Shengmian |
| author_facet | ZHENG Xiuli, YAO Zhiyuan, WU Mingli, ER Limian, LI Shengmian |
| author_sort | ZHENG Xiuli, YAO Zhiyuan, WU Mingli, ER Limian, LI Shengmian |
| collection | DOAJ |
| description | Background and purpose: In recent years, the incidence of rectal neuroendocrine neoplasm (R-NEN) has been on the rise. However, its treatment remains controversial, especially for tumors of 10-20 mm in diameter. In this study, the clinicopathological characteristics of R-NEN were analyzed, the risk factors for lymph node metastasis were discussed, and the effects of different endoscopic resection were compared, so as to ascertain the indications and methods of endoscopic treatment of R-NEN. Methods: Clinical data of patients with R-NEN treated in the Fourth Hospital of Hebei Medical University from February 2007 to December 2020 were collected and retrospectively analyzed. The risk factors of lymph node metastasis were analyzed, and the safety and effectiveness of different endoscopic resection methods were compared. Results: The clinicopathological features of 190 patients with R-NEN were analyzed, suggesting that tumor size ≥12.5 mm (OR = 69.081, 95% CI: 11.385-419.155, P<0.001) and lymphovascular invasion (OR = 11.732, 95% CI: 1.028-84.567, P = 0.015) were independent risk factors for lymph node metastasis. The clinical data of 114 patients with R-NEN treated with endoscopic mucosal resection with cap (EMR-c) and endoscopic submucosal dissection (ESD) respectively were compared. The results showed that the duration of operation was significantly shorter in EMR-c group than in ESD group [(10.23±1.99) min vs (24.78±8.09) min, P<0.001]. There was no significant difference in rate of endoscopic en bloc resection, pathological complete resection rate and complication rate between the two groups (P>0.05). Conclusion: Tumor size ≥12.5 mm in diameter and presence of lymphovascular invasion are independent risk factors for lymph node metastasis in patients with R-NEN. Both EMR-c and ESD are safe and effective treatments for R-NEN of <12.5 mm in diameter and without lymph node metastasis. |
| first_indexed | 2024-04-11T23:51:09Z |
| format | Article |
| id | doaj.art-7a08763f90104188b3b80ed4b0f65b3a |
| institution | Directory Open Access Journal |
| issn | 1007-3639 |
| language | English |
| last_indexed | 2024-04-11T23:51:09Z |
| publishDate | 2022-09-01 |
| publisher | Editorial Office of China Oncology |
| record_format | Article |
| series | Zhongguo aizheng zazhi |
| spelling | doaj.art-7a08763f90104188b3b80ed4b0f65b3a2022-12-22T03:56:29ZengEditorial Office of China OncologyZhongguo aizheng zazhi1007-36392022-09-0132980080610.19401/j.cnki.1007-3639.2022.09.007Analysis of risk factors of lymph node metastasis and comparison of endoscopic resection methods in rectal neuroendocrine neoplasmZHENG Xiuli, YAO Zhiyuan, WU Mingli, ER Limian, LI Shengmian01. Department of Endoscopy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050035, Hebei Province, China;2. Department of Gastroenterology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050035, Hebei Province, ChinaBackground and purpose: In recent years, the incidence of rectal neuroendocrine neoplasm (R-NEN) has been on the rise. However, its treatment remains controversial, especially for tumors of 10-20 mm in diameter. In this study, the clinicopathological characteristics of R-NEN were analyzed, the risk factors for lymph node metastasis were discussed, and the effects of different endoscopic resection were compared, so as to ascertain the indications and methods of endoscopic treatment of R-NEN. Methods: Clinical data of patients with R-NEN treated in the Fourth Hospital of Hebei Medical University from February 2007 to December 2020 were collected and retrospectively analyzed. The risk factors of lymph node metastasis were analyzed, and the safety and effectiveness of different endoscopic resection methods were compared. Results: The clinicopathological features of 190 patients with R-NEN were analyzed, suggesting that tumor size ≥12.5 mm (OR = 69.081, 95% CI: 11.385-419.155, P<0.001) and lymphovascular invasion (OR = 11.732, 95% CI: 1.028-84.567, P = 0.015) were independent risk factors for lymph node metastasis. The clinical data of 114 patients with R-NEN treated with endoscopic mucosal resection with cap (EMR-c) and endoscopic submucosal dissection (ESD) respectively were compared. The results showed that the duration of operation was significantly shorter in EMR-c group than in ESD group [(10.23±1.99) min vs (24.78±8.09) min, P<0.001]. There was no significant difference in rate of endoscopic en bloc resection, pathological complete resection rate and complication rate between the two groups (P>0.05). Conclusion: Tumor size ≥12.5 mm in diameter and presence of lymphovascular invasion are independent risk factors for lymph node metastasis in patients with R-NEN. Both EMR-c and ESD are safe and effective treatments for R-NEN of <12.5 mm in diameter and without lymph node metastasis.http://www.china-oncology.com/fileup/1007-3639/PDF/1666588252284-1289049405.pdf|rectal neuroendocrine neoplasms|lymph node metastasis|endoscopic resection |
| spellingShingle | ZHENG Xiuli, YAO Zhiyuan, WU Mingli, ER Limian, LI Shengmian Analysis of risk factors of lymph node metastasis and comparison of endoscopic resection methods in rectal neuroendocrine neoplasm Zhongguo aizheng zazhi |rectal neuroendocrine neoplasms|lymph node metastasis|endoscopic resection |
| title | Analysis of risk factors of lymph node metastasis and comparison of endoscopic resection methods in rectal neuroendocrine neoplasm |
| title_full | Analysis of risk factors of lymph node metastasis and comparison of endoscopic resection methods in rectal neuroendocrine neoplasm |
| title_fullStr | Analysis of risk factors of lymph node metastasis and comparison of endoscopic resection methods in rectal neuroendocrine neoplasm |
| title_full_unstemmed | Analysis of risk factors of lymph node metastasis and comparison of endoscopic resection methods in rectal neuroendocrine neoplasm |
| title_short | Analysis of risk factors of lymph node metastasis and comparison of endoscopic resection methods in rectal neuroendocrine neoplasm |
| title_sort | analysis of risk factors of lymph node metastasis and comparison of endoscopic resection methods in rectal neuroendocrine neoplasm |
| topic | |rectal neuroendocrine neoplasms|lymph node metastasis|endoscopic resection |
| url | http://www.china-oncology.com/fileup/1007-3639/PDF/1666588252284-1289049405.pdf |
| work_keys_str_mv | AT zhengxiuliyaozhiyuanwuminglierlimianlishengmian analysisofriskfactorsoflymphnodemetastasisandcomparisonofendoscopicresectionmethodsinrectalneuroendocrineneoplasm |