The Novel Association of Early Apoptotic Circulating Tumor Cells with Treatment Outcomes in Breast Cancer Patients
Stemness and epithelial–mesenchymal plasticity are widely studied in the circulating tumor cells of breast cancer patients because the roles of both processes in tumor progression are well established. An important property that should be taken into account is the ability of CTCs to disseminate, par...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/16/9475 |
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| author | Evgeniya S. Grigoryeva Liubov A. Tashireva Vladimir V. Alifanov Olga E. Savelieva Sergey V. Vtorushin Marina V. Zavyalova Nadezhda V. Cherdyntseva Vladimir M. Perelmuter |
| author_facet | Evgeniya S. Grigoryeva Liubov A. Tashireva Vladimir V. Alifanov Olga E. Savelieva Sergey V. Vtorushin Marina V. Zavyalova Nadezhda V. Cherdyntseva Vladimir M. Perelmuter |
| author_sort | Evgeniya S. Grigoryeva |
| collection | DOAJ |
| description | Stemness and epithelial–mesenchymal plasticity are widely studied in the circulating tumor cells of breast cancer patients because the roles of both processes in tumor progression are well established. An important property that should be taken into account is the ability of CTCs to disseminate, particularly the viability and apoptotic states of circulating tumor cells (CTCs). Recent data demonstrate that apoptosis reversal promotes the formation of stem-like tumor cells with pronounced potential for dissemination. Our study focused on the association between different apoptotic states of CTCs with short- and long-term treatment outcomes. We evaluated the association of viable CTCs, CTCs with early features of apoptosis, and end-stage apoptosis/necrosis CTCs with clinicopathological parameters of breast cancer patients. We found that the proportion of circulating tumor cells with features of early apoptosis is a perspective prognosticator of metastasis-free survival, which also correlates with the neoadjuvant chemotherapy response in breast cancer patients. Moreover, we establish that apoptotic CTCs are associated with the poor response to neoadjuvant chemotherapy, and metastasis-free survival expressed at least two stemness markers, CD44 and CD133. |
| first_indexed | 2024-03-09T04:18:03Z |
| format | Article |
| id | doaj.art-7a09188a8bad44de81034733af87a4a5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:18:03Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7a09188a8bad44de81034733af87a4a52023-12-03T13:50:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012316947510.3390/ijms23169475The Novel Association of Early Apoptotic Circulating Tumor Cells with Treatment Outcomes in Breast Cancer PatientsEvgeniya S. Grigoryeva0Liubov A. Tashireva1Vladimir V. Alifanov2Olga E. Savelieva3Sergey V. Vtorushin4Marina V. Zavyalova5Nadezhda V. Cherdyntseva6Vladimir M. Perelmuter7The Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, RussiaThe Department of General and Molecular Pathology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, RussiaThe Department of General and Molecular Pathology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, RussiaThe Department of General and Molecular Pathology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, RussiaThe Department of General and Molecular Pathology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, RussiaThe Department of General and Molecular Pathology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, RussiaThe Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, RussiaThe Department of General and Molecular Pathology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, RussiaStemness and epithelial–mesenchymal plasticity are widely studied in the circulating tumor cells of breast cancer patients because the roles of both processes in tumor progression are well established. An important property that should be taken into account is the ability of CTCs to disseminate, particularly the viability and apoptotic states of circulating tumor cells (CTCs). Recent data demonstrate that apoptosis reversal promotes the formation of stem-like tumor cells with pronounced potential for dissemination. Our study focused on the association between different apoptotic states of CTCs with short- and long-term treatment outcomes. We evaluated the association of viable CTCs, CTCs with early features of apoptosis, and end-stage apoptosis/necrosis CTCs with clinicopathological parameters of breast cancer patients. We found that the proportion of circulating tumor cells with features of early apoptosis is a perspective prognosticator of metastasis-free survival, which also correlates with the neoadjuvant chemotherapy response in breast cancer patients. Moreover, we establish that apoptotic CTCs are associated with the poor response to neoadjuvant chemotherapy, and metastasis-free survival expressed at least two stemness markers, CD44 and CD133.https://www.mdpi.com/1422-0067/23/16/9475breast cancermetastasiscirculating tumor cellsapoptosis |
| spellingShingle | Evgeniya S. Grigoryeva Liubov A. Tashireva Vladimir V. Alifanov Olga E. Savelieva Sergey V. Vtorushin Marina V. Zavyalova Nadezhda V. Cherdyntseva Vladimir M. Perelmuter The Novel Association of Early Apoptotic Circulating Tumor Cells with Treatment Outcomes in Breast Cancer Patients International Journal of Molecular Sciences breast cancer metastasis circulating tumor cells apoptosis |
| title | The Novel Association of Early Apoptotic Circulating Tumor Cells with Treatment Outcomes in Breast Cancer Patients |
| title_full | The Novel Association of Early Apoptotic Circulating Tumor Cells with Treatment Outcomes in Breast Cancer Patients |
| title_fullStr | The Novel Association of Early Apoptotic Circulating Tumor Cells with Treatment Outcomes in Breast Cancer Patients |
| title_full_unstemmed | The Novel Association of Early Apoptotic Circulating Tumor Cells with Treatment Outcomes in Breast Cancer Patients |
| title_short | The Novel Association of Early Apoptotic Circulating Tumor Cells with Treatment Outcomes in Breast Cancer Patients |
| title_sort | novel association of early apoptotic circulating tumor cells with treatment outcomes in breast cancer patients |
| topic | breast cancer metastasis circulating tumor cells apoptosis |
| url | https://www.mdpi.com/1422-0067/23/16/9475 |
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