Anti-mutagenic Activity of Oxycarotenoid-rich Extracts Isolated from Coriandrum Sativum and Murraya koenigii
Introduction: Edible and medicinal plants contain active principles that can act as antimutagens, and hence their intake may be useful for human cancer prevention. Green leafy vegetables are important sources of carotenoids which possess antioxidant, anti-inflammatory and antimutagenic properties....
| Автори: | , , , |
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| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
West Asia Organization for Cancer Prevention
2020-12-01
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| Серія: | Asian Pacific Journal of Cancer Biology |
| Предмети: | |
| Онлайн доступ: | http://www.waocp.com/journal/index.php/apjcb/article/view/578 |
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| author | Anusha Anish Sherena Padinjarevattom Abdulkadir Annamala Panthapulakkil Theru Mukkadan Joseph Kurian |
| author_facet | Anusha Anish Sherena Padinjarevattom Abdulkadir Annamala Panthapulakkil Theru Mukkadan Joseph Kurian |
| author_sort | Anusha Anish |
| collection | DOAJ |
| description | Introduction: Edible and medicinal plants contain active principles that can act as antimutagens, and hence their intake may be useful for human cancer prevention. Green leafy vegetables are important sources of carotenoids which possess antioxidant, anti-inflammatory and antimutagenic properties.
Objective: To study the antimutagenic activity of oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves).
Methods: Oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) were investigated for antimutagenic activity in vitro by Ames test using Salmonella typhimurium strains TA 98 and TA 1535. Mutagens used were, nitro-o- phenylenediamine (NPD) (20μg/plate) and N-methyl- N-nitro-N-nitrosoguanidine (MNNG) (1μg/ plate).
Results: The results revealed that oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) administered at doses of 1.0 mg, 2.5 mg and 5 mg per plate significantly inhibited mutagenicity induced by NPD and MNNG.
Conclusion: These findings suggest that oxycarotenoid- rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) have antimutagenic properties. |
| first_indexed | 2024-03-08T10:13:41Z |
| format | Article |
| id | doaj.art-7a097a1d44ce4e919e3a5f03e1d2f62c |
| institution | Directory Open Access Journal |
| issn | 2538-4635 |
| language | English |
| last_indexed | 2024-03-08T10:13:41Z |
| publishDate | 2020-12-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Biology |
| spelling | doaj.art-7a097a1d44ce4e919e3a5f03e1d2f62c2024-01-29T06:16:01ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Biology2538-46352020-12-015414715210.31557/apjcb.2020.5.4.147-152578Anti-mutagenic Activity of Oxycarotenoid-rich Extracts Isolated from Coriandrum Sativum and Murraya koenigiiAnusha Anish0Sherena Padinjarevattom Abdulkadir1Annamala Panthapulakkil Theru2Mukkadan Joseph Kurian3PK Das Institute of Medical Sciences, Palakkad, India.Department of Biochemistry, Little Flower Medical Research Centre, Angamaly, India.Department of Biochemistry, Jubilee Mission Medical College, Thrissur, India.Research Director, Little Flower Medical Research Centre, Angamaly, IndiaIntroduction: Edible and medicinal plants contain active principles that can act as antimutagens, and hence their intake may be useful for human cancer prevention. Green leafy vegetables are important sources of carotenoids which possess antioxidant, anti-inflammatory and antimutagenic properties. Objective: To study the antimutagenic activity of oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves). Methods: Oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) were investigated for antimutagenic activity in vitro by Ames test using Salmonella typhimurium strains TA 98 and TA 1535. Mutagens used were, nitro-o- phenylenediamine (NPD) (20μg/plate) and N-methyl- N-nitro-N-nitrosoguanidine (MNNG) (1μg/ plate). Results: The results revealed that oxycarotenoid-rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) administered at doses of 1.0 mg, 2.5 mg and 5 mg per plate significantly inhibited mutagenicity induced by NPD and MNNG. Conclusion: These findings suggest that oxycarotenoid- rich extracts isolated from Coriandrum sativum (coriander leaves) and Murraya koenigii (curry leaves) have antimutagenic properties.http://www.waocp.com/journal/index.php/apjcb/article/view/578oxy-carotenoids, coriandrum sativum, murraya koenigi, anti-mutagenic activity, ames test |
| spellingShingle | Anusha Anish Sherena Padinjarevattom Abdulkadir Annamala Panthapulakkil Theru Mukkadan Joseph Kurian Anti-mutagenic Activity of Oxycarotenoid-rich Extracts Isolated from Coriandrum Sativum and Murraya koenigii Asian Pacific Journal of Cancer Biology oxy-carotenoids, coriandrum sativum, murraya koenigi, anti-mutagenic activity, ames test |
| title | Anti-mutagenic Activity of Oxycarotenoid-rich Extracts Isolated from Coriandrum Sativum and Murraya koenigii |
| title_full | Anti-mutagenic Activity of Oxycarotenoid-rich Extracts Isolated from Coriandrum Sativum and Murraya koenigii |
| title_fullStr | Anti-mutagenic Activity of Oxycarotenoid-rich Extracts Isolated from Coriandrum Sativum and Murraya koenigii |
| title_full_unstemmed | Anti-mutagenic Activity of Oxycarotenoid-rich Extracts Isolated from Coriandrum Sativum and Murraya koenigii |
| title_short | Anti-mutagenic Activity of Oxycarotenoid-rich Extracts Isolated from Coriandrum Sativum and Murraya koenigii |
| title_sort | anti mutagenic activity of oxycarotenoid rich extracts isolated from coriandrum sativum and murraya koenigii |
| topic | oxy-carotenoids, coriandrum sativum, murraya koenigi, anti-mutagenic activity, ames test |
| url | http://www.waocp.com/journal/index.php/apjcb/article/view/578 |
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