Immune response plays a role in Mycoplasma pneumoniae pneumonia
IntroductionMycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP.Method...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1189647/full |
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| author | Yifan Zhu Yingying Luo Ling Li Xinyi Jiang Yi Du Jing Wang Huilin Li Haiyan Gu Daiying Li Heng Tang Houbing Qin Changdi Xu Yan Liu Deyu Zhao Yun Guo Feng Liu |
| author_facet | Yifan Zhu Yingying Luo Ling Li Xinyi Jiang Yi Du Jing Wang Huilin Li Haiyan Gu Daiying Li Heng Tang Houbing Qin Changdi Xu Yan Liu Deyu Zhao Yun Guo Feng Liu |
| author_sort | Yifan Zhu |
| collection | DOAJ |
| description | IntroductionMycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP.MethodsThis self-controlled study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from the severe side (SD) and opposite side (OD) of 41 children with MPP from January to December 2021 and revealed the differences of the peripheral blood neutrophil function among children with mild MPP, severe MPP, and healthy children through transcriptome sequencing.ResultsThe MP load or the pulmonary microbiota had no significant difference between the SD group and OD group, and the deterioration of MPP was related to the immune response, especially the intrinsic immune response.DiscussionThe immune response plays a role in MPP, which may inform treatment strategies for MPP. |
| first_indexed | 2024-03-13T09:28:16Z |
| format | Article |
| id | doaj.art-7a0afb2839784f1da26903bc891407e9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T09:28:16Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7a0afb2839784f1da26903bc891407e92023-05-26T04:44:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11896471189647Immune response plays a role in Mycoplasma pneumoniae pneumoniaYifan Zhu0Yingying Luo1Ling Li2Xinyi Jiang3Yi Du4Jing Wang5Huilin Li6Haiyan Gu7Daiying Li8Heng Tang9Houbing Qin10Changdi Xu11Yan Liu12Deyu Zhao13Yun Guo14Feng Liu15Department of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, The Affiliated Wuxi Children’s Hospital of Nanjing Medical University, Wuxi, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaVision Medicals Center for Infectious Diseases, Guangzhou, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Respiratory Medicine, The Affiliated Wuxi Children’s Hospital of Nanjing Medical University, Wuxi, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, ChinaIntroductionMycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP.MethodsThis self-controlled study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from the severe side (SD) and opposite side (OD) of 41 children with MPP from January to December 2021 and revealed the differences of the peripheral blood neutrophil function among children with mild MPP, severe MPP, and healthy children through transcriptome sequencing.ResultsThe MP load or the pulmonary microbiota had no significant difference between the SD group and OD group, and the deterioration of MPP was related to the immune response, especially the intrinsic immune response.DiscussionThe immune response plays a role in MPP, which may inform treatment strategies for MPP.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1189647/fullMycoplasma pneumoniae pneumoniamicrobiometranscriptomethe immune responseMycoplasma pneumoniae |
| spellingShingle | Yifan Zhu Yingying Luo Ling Li Xinyi Jiang Yi Du Jing Wang Huilin Li Haiyan Gu Daiying Li Heng Tang Houbing Qin Changdi Xu Yan Liu Deyu Zhao Yun Guo Feng Liu Immune response plays a role in Mycoplasma pneumoniae pneumonia Frontiers in Immunology Mycoplasma pneumoniae pneumonia microbiome transcriptome the immune response Mycoplasma pneumoniae |
| title | Immune response plays a role in Mycoplasma pneumoniae pneumonia |
| title_full | Immune response plays a role in Mycoplasma pneumoniae pneumonia |
| title_fullStr | Immune response plays a role in Mycoplasma pneumoniae pneumonia |
| title_full_unstemmed | Immune response plays a role in Mycoplasma pneumoniae pneumonia |
| title_short | Immune response plays a role in Mycoplasma pneumoniae pneumonia |
| title_sort | immune response plays a role in mycoplasma pneumoniae pneumonia |
| topic | Mycoplasma pneumoniae pneumonia microbiome transcriptome the immune response Mycoplasma pneumoniae |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1189647/full |
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