Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines
A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1–25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence...
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| Format: | Article |
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MDPI AG
2013-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/18/2/1434 |
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| author | Moustafa M. G. Fouda Mohamed A. Marzouk Mohamed A. Al-Omar Amer M. Alanazi Rashad A. Al-Salahi Amira M. Gamal-Eldeen |
| author_facet | Moustafa M. G. Fouda Mohamed A. Marzouk Mohamed A. Al-Omar Amer M. Alanazi Rashad A. Al-Salahi Amira M. Gamal-Eldeen |
| author_sort | Moustafa M. G. Fouda |
| collection | DOAJ |
| description | A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1–25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 6–8 and 25 are promising multi-potent anti-inflammatory agents. |
| first_indexed | 2024-12-11T01:43:27Z |
| format | Article |
| id | doaj.art-7a0c37c889a6431b9e33b51d4faba431 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T01:43:27Z |
| publishDate | 2013-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7a0c37c889a6431b9e33b51d4faba4312022-12-22T01:24:58ZengMDPI AGMolecules1420-30492013-01-011821434144610.3390/molecules18021434Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolinesMoustafa M. G. FoudaMohamed A. MarzoukMohamed A. Al-OmarAmer M. AlanaziRashad A. Al-SalahiAmira M. Gamal-EldeenA series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1–25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 6–8 and 25 are promising multi-potent anti-inflammatory agents.http://www.mdpi.com/1420-3049/18/2/14341,2,4-triazoloquinazolineantitumorHep-G2HCT-116inflammation |
| spellingShingle | Moustafa M. G. Fouda Mohamed A. Marzouk Mohamed A. Al-Omar Amer M. Alanazi Rashad A. Al-Salahi Amira M. Gamal-Eldeen Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines Molecules 1,2,4-triazoloquinazoline antitumor Hep-G2 HCT-116 inflammation |
| title | Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines |
| title_full | Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines |
| title_fullStr | Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines |
| title_full_unstemmed | Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines |
| title_short | Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines |
| title_sort | cytotoxicity and anti inflammatory activity of methylsulfanyl triazoloquinazolines |
| topic | 1,2,4-triazoloquinazoline antitumor Hep-G2 HCT-116 inflammation |
| url | http://www.mdpi.com/1420-3049/18/2/1434 |
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