Frequency of Delirium Associated with Dexmedetomidine and Propofol in Post CABG Patients: A Comparative Study
Objective: To find out the frequency of delirium associated with peri-operative use of dexmetedomidine and propofol in post CABG patients. Study Design: Comparative Cross-sectional study. Place and Duration of Study: Adult Intensive Care unit, Department of Cardiac Anesthesiology and Intensiv...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2022-11-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://pafmj.org/index.php/PAFMJ/article/view/9562 |
| _version_ | 1797938539619418112 |
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| author | Noor-Ul- Ain Syed Muzaffar r Hasan Kirmani Ayesha Siddique M Umer Siddique Rehana Javaid M Aamir Khan |
| author_facet | Noor-Ul- Ain Syed Muzaffar r Hasan Kirmani Ayesha Siddique M Umer Siddique Rehana Javaid M Aamir Khan |
| author_sort | Noor-Ul- Ain |
| collection | DOAJ |
| description |
Objective: To find out the frequency of delirium associated with peri-operative use of dexmetedomidine and propofol in post CABG patients.
Study Design: Comparative Cross-sectional study.
Place and Duration of Study: Adult Intensive Care unit, Department of Cardiac Anesthesiology and Intensive Care, Armed Force Institute of Cardiology, Rawalpindi Pakistan from Feb to Jun 2022.
Methodology: All post CABG patients who have undergone elective surgery were included through non-probability consecutive sampling technique. All the delirious patients amongst them were subjected to a modified version of ICU-CAM to establish post-operative delirium (POD) caused by either dexmedetomidine or propofol. POD in both the category of patients
was compared.
Results: A total of 179 CABG patients were included in our study. 140(78.2%) of the patients were subjected to the use of dexmedetomidine throughout their surgery while 39(21.8%) of the patients were given propofol. After subjecting the patients to our exclusion criteria which aimed to eliminate the confounding causes of POD in post-CABG patients, only 30(16.8%) had delirium while 149(83.2%) didn’t develop delirium (p-value=0.003). Majority of the delirious patients were given dexmedetomidine (n=29; 20.77%) in the operation theatre while only a fraction (n=1; 2.58%) were given propofol. Average duration of ICU stay in our study population was 5 days. 15(8.4%) cases out of our total study population underwent reintubation and re-ventilation because of low cardiac output or respiratory distress.
Conclusion: Dexmedetomidine could possibly be associated with POD in patients undergoing cardiac surgery. Propofol on
the other hand is considerably safe in this regard and doesn’t cause POD.
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| first_indexed | 2024-04-10T19:02:24Z |
| format | Article |
| id | doaj.art-7a0c4e66c0644ee99bf6a6eadcd4847a |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-04-10T19:02:24Z |
| publishDate | 2022-11-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-7a0c4e66c0644ee99bf6a6eadcd4847a2023-01-31T08:22:48ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422022-11-0172SUPPL-310.51253/pafmj.v72iSUPPL-3.9562Frequency of Delirium Associated with Dexmedetomidine and Propofol in Post CABG Patients: A Comparative StudyNoor-Ul- Ain0Syed Muzaffar r Hasan Kirmani1Ayesha Siddique2M Umer Siddique3Rehana Javaid4M Aamir Khan5Armed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi PakistanDivisional Headquarters Teaching Hospital, Mirpur, Azad Jammu KashmirQuaid-e-Azam Medical College, Bahawalpur PakistanArmed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Cardiology/National Institute of Heart Diseases (AFIC/NIHD)/National University of Medical Sciences (NUMS) Rawalpindi Pakistan Objective: To find out the frequency of delirium associated with peri-operative use of dexmetedomidine and propofol in post CABG patients. Study Design: Comparative Cross-sectional study. Place and Duration of Study: Adult Intensive Care unit, Department of Cardiac Anesthesiology and Intensive Care, Armed Force Institute of Cardiology, Rawalpindi Pakistan from Feb to Jun 2022. Methodology: All post CABG patients who have undergone elective surgery were included through non-probability consecutive sampling technique. All the delirious patients amongst them were subjected to a modified version of ICU-CAM to establish post-operative delirium (POD) caused by either dexmedetomidine or propofol. POD in both the category of patients was compared. Results: A total of 179 CABG patients were included in our study. 140(78.2%) of the patients were subjected to the use of dexmedetomidine throughout their surgery while 39(21.8%) of the patients were given propofol. After subjecting the patients to our exclusion criteria which aimed to eliminate the confounding causes of POD in post-CABG patients, only 30(16.8%) had delirium while 149(83.2%) didn’t develop delirium (p-value=0.003). Majority of the delirious patients were given dexmedetomidine (n=29; 20.77%) in the operation theatre while only a fraction (n=1; 2.58%) were given propofol. Average duration of ICU stay in our study population was 5 days. 15(8.4%) cases out of our total study population underwent reintubation and re-ventilation because of low cardiac output or respiratory distress. Conclusion: Dexmedetomidine could possibly be associated with POD in patients undergoing cardiac surgery. Propofol on the other hand is considerably safe in this regard and doesn’t cause POD. https://pafmj.org/index.php/PAFMJ/article/view/9562Cardiac surgeryDexmedetomidinePost-operative delirium |
| spellingShingle | Noor-Ul- Ain Syed Muzaffar r Hasan Kirmani Ayesha Siddique M Umer Siddique Rehana Javaid M Aamir Khan Frequency of Delirium Associated with Dexmedetomidine and Propofol in Post CABG Patients: A Comparative Study Pakistan Armed Forces Medical Journal Cardiac surgery Dexmedetomidine Post-operative delirium |
| title | Frequency of Delirium Associated with Dexmedetomidine and Propofol in Post CABG Patients: A Comparative Study |
| title_full | Frequency of Delirium Associated with Dexmedetomidine and Propofol in Post CABG Patients: A Comparative Study |
| title_fullStr | Frequency of Delirium Associated with Dexmedetomidine and Propofol in Post CABG Patients: A Comparative Study |
| title_full_unstemmed | Frequency of Delirium Associated with Dexmedetomidine and Propofol in Post CABG Patients: A Comparative Study |
| title_short | Frequency of Delirium Associated with Dexmedetomidine and Propofol in Post CABG Patients: A Comparative Study |
| title_sort | frequency of delirium associated with dexmedetomidine and propofol in post cabg patients a comparative study |
| topic | Cardiac surgery Dexmedetomidine Post-operative delirium |
| url | https://pafmj.org/index.php/PAFMJ/article/view/9562 |
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