Protective effects of Otophylloside N on pentylenetetrazol-induced neuronal injury in vitro and in vivo

Protective effects of Otophylloside N on pentylenetetrazol-induced neuronal injury in vitro and in vivo

Approximately 30% of epileptic patients worldwide are medically unable to control their seizures. In addition, repeated epileptic seizures generally lead to neural damage. Pentylenetetrazol (PTZ) is a clinical circulatory and respiratory stimulant that is experimentally used to mimic epileptic convu...

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Bibliographic Details
Main Authors: Feiya Sheng, Mengting Chen, Yuan Tan, Cheng Xiang, Mi Zhang, Baocai Li, Huanxing Su, Chengwei He, Jianbo Wan, Peng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Pharmacology
Subjects:
Apoptosis
Epilepsy
pentylenetetrazol
Neuroprotective effect
Cynanchum otophyllum Schneid
Otophylloside N
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00224/full

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