Hepatitis C Virus Infection And Metabolic Syndrome—A Community-Based Study in an Endemic Area of Taiwan
Metabolic syndrome (MS) is a complicated disorder associated with a high risk of future development of micro- and macrovascular complications. The extrahepatic manifestations of hepatitis C virus (HCV) infection can include multiple metabolic abnormalities. However, the extent, severity, and charact...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-06-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X09705200 |
| _version_ | 1811345254786269184 |
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| author | Jee-Fu Huang Wan-Long Chuang Ming-Lung Yu Sung-Hua Yu Chung-Feng Huang Ching-I Huang Ming-Lun Yeh Meng-Hsuan Hsieh Jeng-Fu Yang Zu-Yau Lin Shinn-Chern Chen Chia-Yen Dai Wen-Yu Chang |
| author_facet | Jee-Fu Huang Wan-Long Chuang Ming-Lung Yu Sung-Hua Yu Chung-Feng Huang Ching-I Huang Ming-Lun Yeh Meng-Hsuan Hsieh Jeng-Fu Yang Zu-Yau Lin Shinn-Chern Chen Chia-Yen Dai Wen-Yu Chang |
| author_sort | Jee-Fu Huang |
| collection | DOAJ |
| description | Metabolic syndrome (MS) is a complicated disorder associated with a high risk of future development of micro- and macrovascular complications. The extrahepatic manifestations of hepatitis C virus (HCV) infection can include multiple metabolic abnormalities. However, the extent, severity, and characteristics of MS in HCV-infected patients have rarely been investigated in community-based settings. This study aimed to determine the difference in prevalence and distribution of the components of MS between HCV-infected patients and healthy controls. Multipurpose mass screening of adults was conducted in an HCV-endemic area of Southern Taiwan. Clinical profiles in terms of anthropometric data and MS components, as well as viral hepatitis markers, were assessed. Two hundred and thirty-seven adults (94 males; mean age, 55.5 ± 10.8 years) were recruited. The prevalence of anti-HCV seropositivity was 39.2% (93/237). The prevalence of MS was higher in the HCV-infected individuals (24.7%, 23/93) than in the control, uninfected subjects (13.2%, 19/144, p = 0.02). In terms of MS components, HCV-infected subjects had a higher prevalence of high waist circumference (51.6% vs. 25.7%, p < 0.001) and hypertension (58.1% vs. 36.8%, p = 0.001) than controls. Multivariate logistic regression analysis demonstrated that anti-HCV positivity was significantly associated with MS (odds ratio, 6.4; 95% confidence interval, 1.82–22.84; p = 0.004). HCV infection was associated with a higher prevalence of MS. Determination of MS in patients with HCV infection could therefore be indicated. |
| first_indexed | 2024-04-13T20:00:30Z |
| format | Article |
| id | doaj.art-7a110335fdb64a3dbb40e82fa3ebb319 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-04-13T20:00:30Z |
| publishDate | 2009-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-7a110335fdb64a3dbb40e82fa3ebb3192022-12-22T02:32:13ZengWileyKaohsiung Journal of Medical Sciences1607-551X2009-06-0125629930510.1016/S1607-551X(09)70520-0Hepatitis C Virus Infection And Metabolic Syndrome—A Community-Based Study in an Endemic Area of TaiwanJee-Fu Huang0Wan-Long Chuang1Ming-Lung Yu2Sung-Hua Yu3Chung-Feng Huang4Ching-I Huang5Ming-Lun Yeh6Meng-Hsuan Hsieh7Jeng-Fu Yang8Zu-Yau Lin9Shinn-Chern Chen10Chia-Yen Dai11Wen-Yu Chang12Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung, TaiwanDepartment of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung, TaiwanDepartment of Occupational and Environmental Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Preventive Medicine, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung, TaiwanHepatobiliary Division, Department of Internal Medicine, Kaohsiung, TaiwanMetabolic syndrome (MS) is a complicated disorder associated with a high risk of future development of micro- and macrovascular complications. The extrahepatic manifestations of hepatitis C virus (HCV) infection can include multiple metabolic abnormalities. However, the extent, severity, and characteristics of MS in HCV-infected patients have rarely been investigated in community-based settings. This study aimed to determine the difference in prevalence and distribution of the components of MS between HCV-infected patients and healthy controls. Multipurpose mass screening of adults was conducted in an HCV-endemic area of Southern Taiwan. Clinical profiles in terms of anthropometric data and MS components, as well as viral hepatitis markers, were assessed. Two hundred and thirty-seven adults (94 males; mean age, 55.5 ± 10.8 years) were recruited. The prevalence of anti-HCV seropositivity was 39.2% (93/237). The prevalence of MS was higher in the HCV-infected individuals (24.7%, 23/93) than in the control, uninfected subjects (13.2%, 19/144, p = 0.02). In terms of MS components, HCV-infected subjects had a higher prevalence of high waist circumference (51.6% vs. 25.7%, p < 0.001) and hypertension (58.1% vs. 36.8%, p = 0.001) than controls. Multivariate logistic regression analysis demonstrated that anti-HCV positivity was significantly associated with MS (odds ratio, 6.4; 95% confidence interval, 1.82–22.84; p = 0.004). HCV infection was associated with a higher prevalence of MS. Determination of MS in patients with HCV infection could therefore be indicated.http://www.sciencedirect.com/science/article/pii/S1607551X09705200hepatitis C virusinsulin resistancemetabolic syndrome |
| spellingShingle | Jee-Fu Huang Wan-Long Chuang Ming-Lung Yu Sung-Hua Yu Chung-Feng Huang Ching-I Huang Ming-Lun Yeh Meng-Hsuan Hsieh Jeng-Fu Yang Zu-Yau Lin Shinn-Chern Chen Chia-Yen Dai Wen-Yu Chang Hepatitis C Virus Infection And Metabolic Syndrome—A Community-Based Study in an Endemic Area of Taiwan Kaohsiung Journal of Medical Sciences hepatitis C virus insulin resistance metabolic syndrome |
| title | Hepatitis C Virus Infection And Metabolic Syndrome—A Community-Based Study in an Endemic Area of Taiwan |
| title_full | Hepatitis C Virus Infection And Metabolic Syndrome—A Community-Based Study in an Endemic Area of Taiwan |
| title_fullStr | Hepatitis C Virus Infection And Metabolic Syndrome—A Community-Based Study in an Endemic Area of Taiwan |
| title_full_unstemmed | Hepatitis C Virus Infection And Metabolic Syndrome—A Community-Based Study in an Endemic Area of Taiwan |
| title_short | Hepatitis C Virus Infection And Metabolic Syndrome—A Community-Based Study in an Endemic Area of Taiwan |
| title_sort | hepatitis c virus infection and metabolic syndrome a community based study in an endemic area of taiwan |
| topic | hepatitis C virus insulin resistance metabolic syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X09705200 |
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