Does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower- and upper-middle income countries with limited resources? Our experience and literature review
Colorectal carcinoma in children and adolescents is extremely rare, with an annual incidence <0.3 cases per million, most frequently reported in the second decade of life. It accounts for severe morbidity and poor prognosis owing to the low index of suspicion, delayed diagnosis, advanced stage at...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-12-01
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| Series: | Journal of the Egyptian National Cancer Institute |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110036217300754 |
| _version_ | 1818127957909045248 |
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| author | Yacoob Omar Carrim Luvo Gaxa Francisca van der Schyff Nndweleni Meshack Bida Fareed Omar Zarina Lockhat |
| author_facet | Yacoob Omar Carrim Luvo Gaxa Francisca van der Schyff Nndweleni Meshack Bida Fareed Omar Zarina Lockhat |
| author_sort | Yacoob Omar Carrim |
| collection | DOAJ |
| description | Colorectal carcinoma in children and adolescents is extremely rare, with an annual incidence <0.3 cases per million, most frequently reported in the second decade of life. It accounts for severe morbidity and poor prognosis owing to the low index of suspicion, delayed diagnosis, advanced stage at presentation and the aggressive tumor nature. Patients present with abdominal pain, vomiting, constipation, abdominal distension, rectal tenesmus, iron-deficiency anemia, change in bowel habit and weight loss. Rectal bleeding is an uncommon presentation in children. Bowel obstruction presents frequently in children compared to adults. In 90% of pediatric cases, colorectal carcinoma occurs sporadically. In 10%, predisposing conditions and syndromes are identified. We present a case study of a 12-year-old female with advanced colorectal cancer without a predisposing disease or syndrome, who received radio-chemotherapy ten weeks prior to radical abdominopelvic surgery, followed by radio-chemotherapy postoperatively, with a positive outcome. |
| first_indexed | 2024-12-11T07:25:37Z |
| format | Article |
| id | doaj.art-7a133384439f40b38d9fed3dd0936cf4 |
| institution | Directory Open Access Journal |
| issn | 1110-0362 |
| language | English |
| last_indexed | 2024-12-11T07:25:37Z |
| publishDate | 2017-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of the Egyptian National Cancer Institute |
| spelling | doaj.art-7a133384439f40b38d9fed3dd0936cf42022-12-22T01:15:58ZengSpringerOpenJournal of the Egyptian National Cancer Institute1110-03622017-12-0129420120610.1016/j.jnci.2017.11.002Does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower- and upper-middle income countries with limited resources? Our experience and literature reviewYacoob Omar Carrim0Luvo Gaxa1Francisca van der Schyff2Nndweleni Meshack Bida3Fareed Omar4Zarina Lockhat5Department of Radiology, Faculty of Health Sciences, University of Pretoria, Private Bag x323, Arcadia 0007, South AfricaDepartment of Radiology, Faculty of Health Sciences, University of Pretoria, Private Bag x323, Arcadia 0007, South AfricaDepartment of Pediatric Surgery, Faculty of Health Sciences, University of Pretoria, Private Bag x323, Arcadia 0007, South AfricaDivision of Anatomical Pathology, Faculty of Health Sciences, University of Pretoria, Private Bag x323, Arcadia 0007, South AfricaDepartment of Pediatrics and Child Health, Faculty of Health Sciences, University of Pretoria, Private Bag x323, Arcadia 0007, South AfricaDepartment of Radiology, Faculty of Health Sciences, University of Pretoria, Private Bag x323, Arcadia 0007, South AfricaColorectal carcinoma in children and adolescents is extremely rare, with an annual incidence <0.3 cases per million, most frequently reported in the second decade of life. It accounts for severe morbidity and poor prognosis owing to the low index of suspicion, delayed diagnosis, advanced stage at presentation and the aggressive tumor nature. Patients present with abdominal pain, vomiting, constipation, abdominal distension, rectal tenesmus, iron-deficiency anemia, change in bowel habit and weight loss. Rectal bleeding is an uncommon presentation in children. Bowel obstruction presents frequently in children compared to adults. In 90% of pediatric cases, colorectal carcinoma occurs sporadically. In 10%, predisposing conditions and syndromes are identified. We present a case study of a 12-year-old female with advanced colorectal cancer without a predisposing disease or syndrome, who received radio-chemotherapy ten weeks prior to radical abdominopelvic surgery, followed by radio-chemotherapy postoperatively, with a positive outcome.http://www.sciencedirect.com/science/article/pii/S1110036217300754Pediatric colorectal carcinomaNeoadjuvantMucinousFluorodeoxyglucose positron emission tomography (FDG PET) negativeCarcinoembryonic antigen (CEA) |
| spellingShingle | Yacoob Omar Carrim Luvo Gaxa Francisca van der Schyff Nndweleni Meshack Bida Fareed Omar Zarina Lockhat Does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower- and upper-middle income countries with limited resources? Our experience and literature review Journal of the Egyptian National Cancer Institute Pediatric colorectal carcinoma Neoadjuvant Mucinous Fluorodeoxyglucose positron emission tomography (FDG PET) negative Carcinoembryonic antigen (CEA) |
| title | Does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower- and upper-middle income countries with limited resources? Our experience and literature review |
| title_full | Does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower- and upper-middle income countries with limited resources? Our experience and literature review |
| title_fullStr | Does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower- and upper-middle income countries with limited resources? Our experience and literature review |
| title_full_unstemmed | Does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower- and upper-middle income countries with limited resources? Our experience and literature review |
| title_short | Does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower- and upper-middle income countries with limited resources? Our experience and literature review |
| title_sort | does radiotherapy prior to surgery improve long term prognosis in pediatric colorectal cancer in lower and upper middle income countries with limited resources our experience and literature review |
| topic | Pediatric colorectal carcinoma Neoadjuvant Mucinous Fluorodeoxyglucose positron emission tomography (FDG PET) negative Carcinoembryonic antigen (CEA) |
| url | http://www.sciencedirect.com/science/article/pii/S1110036217300754 |
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